PPT-Harnessing the Immune System: Mechanism of Action of Immunotherapies in B-Cell Malignancies

Learning Goals Immunotherapies in BCell Malignancies Available Immunotherapies OS in MM Poor Outcome in HighRisk Myeloma Immunotherapy Potential for Success Without a Targetable Molecular Mutation. What is the Immune System?. Our body’s natural defensive line to foreign material called microbes.. Without an immune system, microbes would quickly attack our bodies.. Our body has three levels of defense against foreign invaders. . Immune Modulation, and Immunosuppression in MS: . A Review . Introduction. Architecture of the Immune System: Focus on Innate Immunity. Innate Immune System Features. Architecture of the Immune System: Focus on Adaptive Immunity. The Future of Cancer Care. Brad . Loncar. Biotech . commentator . and . investor for 8+ . years.. Manager of a biotech-focused family office.. Franklin Templeton Investments and U.S. Department of the Treasury.. Essential Knowledge. 2.d.2 - Homeostatic mechanisms reflect both common ancestry and divergence due to adaptation to different environments (43.3).. 2.d.3 – Biological systems are affected by disruptions to their dynamic homeostasis (43.2-43.4).. Chapter 43. Innate Immunity. nonspecific defense that is active immediately upon infection. found in all animals & plants. includes:. outer covering. skin or shell. chemical secretions. @ openings to interior of body. Key attributes of immune system. 4 attributes that characterize the immune system as a whole. specificity. antigen-antibody specificity. diversity. react to millions of antigens. memory. rapid 2° response. The Immune System CAMPBELL and REECE Chapter 43 Innate Immunity nonspecific defense that is active immediately upon infection found in all animals & plants includes: outer covering skin or shell chemical secretions Key attributes of immune system. 4 attributes that characterize the immune system as a whole. specificity. antigen-antibody specificity. diversity. react to millions of antigens. memory. rapid 2° response. Purpose of the Immune System . Protect from internal attacks from . abnormal body cells . (cancerous cells). Protect from . external pathogens. Can enter the body through any systems that have openings on the exterior of the body. Immunology. Study of the components and function of the immune system. Immune System . Molecules, cells, tissues and organs which provide non-specific and specific protection against. Microorganisms. IND enabling studies of LT-415 a novel chemotherapeutic agent with a unique targetThis project is founded on the identification of a new class of cancer drug leads called the seriniquinones discovered Chapter 21. 2 Defense Systems. Innate Immunity. nonspecific defense that is active immediately upon infection. found in all animals & plants. includes:. outer covering. skin or shell. chemical secretions. innate immunity. Prof dr. . Ihsan. . Edan. . Alsaimary. department of microbiology – college of medicine – university of . basrah. Mobile : 07801410838 - . e.mail. : ihsanalsaimary@gmail.com. Organs and . cells. Peter Kelleher. Senior Lecturer, Imperial . College London, . Chelsea & Westminster . campus. Learning objectives . Illustrate the importance of immunology for human health..  .