Assistant Professor Department of Veterinary Clinical Complex UNIT3 Synonyms FATTY LIVER IN CATTLE FATMOBILIZATION SYNDROME HEPATIC LIPIDOSIS PREGNANCY TOXEMIA IN CATTLE Introduction It is a disease of ID: 1047128
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1. Fat Cow SyndromeDr. Vivek Kr. Singh Assistant ProfessorDepartment of Veterinary Clinical Complex UNIT-3
2. SynonymsFATTY LIVER IN CATTLEFAT-MOBILIZATION SYNDROMEHEPATIC LIPIDOSIS PREGNANCY TOXEMIA IN CATTLE
3. IntroductionIt is a disease of high producing cowsOverfed cattle during dry period may develop fatty liver syndrome just before or after calving (Transition period)
4. EtiologyMobilization of excessive body fat to liver during periods of negative energy balance at time of parturition or in early lactation of dairy cows and late pregnancy of beef cows
5. Pathogenesis Increase energy demands + Reduced feed intake Negative Energy Balance Mobilization of fat from reserve Fat is transported to liver for gluconeogenesis Ruminant liver has limited capacity to transport VLDL Hepatic Lipidosis
6. Clinical findingsAnorexiaDepressionWeaknessPersistent weight lossRecombencyKetosis (Do not respond to glucose treatment)Some animals show nervous signs like star gazing and tremors of head and neckComa and death
7. Necropsy FindingsGross enlargement of liverLiver is pale yellow in colorGreasy and friableHistopathology revealsEnlarged hepatocytes with fatty changes
8. DiagnosisElevated NEFAKetone bodiesEleveted LDHTatal bilirubinASTGGTThe liver sample which floats in water and copper sulphate solution having sp. Gravity ranging between 1.025 – 1.055 indicates presence of 34% lipid content in the sample
9. TreatmentContinuous supplementation of glucose along with calcium and magnesium salt to correct negative energy balanceLong acting protamine zinc insuline @ 200 units/ cow every 12 hrlyS/c administration of choline chloride (25 g in 250 ml NSS)Niacin@ 6-12g/cow/day helps in reducing hepatic lipidosisAntioxidantsAnabolic steroids @300mg/cow
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