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Glucose Homeostasis: In Health, Disease and With Treatment Glucose Homeostasis: In Health, Disease and With Treatment

Glucose Homeostasis: In Health, Disease and With Treatment - PowerPoint Presentation

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Glucose Homeostasis: In Health, Disease and With Treatment - PPT Presentation

Packets Included in this Puzzle A Glucose Metabolism and Cause of Diabetes Types1 and 2 B T he Physiology of Hypoglycemia and Hyperglycemia and Possible points of Diabetes Treatments ID: 912841

cells glucose puzzle blood glucose cells blood puzzle insulin glycogen glucagon type food intestine starch energy kidney store sugar

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Slide1

Glucose Homeostasis: In Health, Disease and With Treatment

Packets Included in this Puzzle:A. Glucose Metabolism and Cause of Diabetes Types1 and 2B. The Physiology of Hypoglycemia and Hyperglycemia; and Possible points of Diabetes Treatments C. Strategies/Drugs for Treating Diabetes (Types 1 and 2)

Slide2

Glucose in Blood

Store as GlycogenProvide energy

Glucose in Cells

Insulin

Glucagon

Starch in food

Glucose in Intestine

Glucose in Kidney

Focus:

Glucose Metabolism Overview and Cause of Diabetes

Types 1

and 2

Cut out the words in each of the boxes, along the solid lines, and arrange them on the Glucose Metabolism Puzzle template so that they represent key steps in Glucose MetabolismCut out the red Type 1 and 2 DM boxes as well as the 2 red X on this page and place them on the Glucose Metabolism assembled puzzle showing where/what is missing or non-functional in the case of Type 1 and Type 2 DM

A

Type 2 DM

Type 1 DM

Glucose Metabolism

(Words)

Glucose Homeostasis Puzzle: Packet

A

Slide3

Glucose in Blood

Store as Glycogen

Provide energy

Glucose in Cells

Glucose uptake

Glycogen breakdown

Insulin

Glucagon

Starch in food

Digestion

Glucose in Intestine

Absorption

Glucose in Kidney

Filtration

Reabsorption

Undigested/unabsorbed glucose to Feces

Excess glucose to Urine

Glucose Metabolism

(Template)

A

Slide4

Glucose in Blood

Store as GlycogenProvide energy

Glucose in Cells

Insulin

Glucagon

Starch in food

Glucose in Intestine

Glucose in Kidney

Glucose Metabolism

(Words)

B

Glucose Homeostasis Puzzle: Packet B

Low Blood Sugar

Pancreatic

a

-cells+

-

High Blood Sugar

Intestinal cells

Pancreatic

b

-cells

DPP-4

In

cretins

(GLP-1, GIP)

+

-

-

Focus

: Glucose Metabolism during Hypoglycemia and Hyperglycemia

AND Possible processes and/or target for developing treatment strategies for

Diabetes

Cut out the words in each of

the boxes, along the solid

lines, and arrange them on the Puzzle templates.

Print 3 copies of this page and cut out the words for the various groups to work on the puzzle in packet B

Slide5

Glucose Metabolism

(Steps)BGlucose Homeostasis Puzzle: Packet B

2. Stages

of puzzle building:

Group 1 handles the puzzle with the hypoglycemia template

Group 2 handles the puzzle with the hyperglycemia template

Groups 1 and 2 come together to assemble the hypo and hyperglycemia pathways on the Hypo- and Hyperglycemia template

Groups 1+2 or a different group should mark the possible points of DM treatment strategies. They present this to the class.

Slide6

Glucose in Blood

Store as GlycogenProvide energy

Glucose in Cells

Glucose uptake

Glycogen breakdown

Insulin

Glucagon

Low Blood Sugar

Pancreatic

a

-cells

Starch in food

Digestion

Glucose in Intestine

Absorption

Glucose in Kidney

Filtration

Reabsorption

Undigested/unabsorbed glucose to Feces

Excess glucose to Urine

+

-

Hypoglycemia

B

Slide7

Glucose in Blood

Store as Glycogen

Provide energy

Glucose in Cells

Glucose uptake

Glycogen breakdown

Insulin

Glucagon

High Blood Sugar

Intestinal cells

Pancreatic

b

-cells

DPP-4

Starch in food

Digestion

Glucose in Intestine

Absorption

In

cretins

(GLP-1, GIP)

Glucose in Kidney

Filtration

Reabsorption

Undigested/unabsorbed glucose to Feces

Excess glucose to Urine

Proteolysis

+

-

-

Hyperglycemia

B

Slide8

Glucose in Blood

Store as Glycogen

Provide energy

Glucose in Cells

Glucose uptake

Glycogen breakdown

Insulin

Glucagon

High Blood Sugar

Intestinal cells

Pancreatic

b

-cells

DPP-4

Low Blood Sugar

Pancreatic

a

-cells

Starch in food

Digestion

Glucose in Intestine

Absorption

In

cretins

(GLP-1, GIP)

Glucose in Kidney

Filtration

Reabsorption

Undigested/unabsorbed glucose to Feces

Excess glucose to Urine

Proteolysis

+

-

-

+

-

Hypo- and Hyperglycemia

B

Slide9

Glucose in Blood

Store as GlycogenProvide energy

Glucose in Cells

Insulin

Glucagon

Starch in food

Glucose in Intestine

Glucose in Kidney

Low Blood Sugar

Pancreatic

a

-cells

+

-

High Blood Sugar

Intestinal cells

Pancreatic

b-cells

DPP-4In

cretins (GLP-1, GIP)

+

-

-

Glucose Homeostasis Puzzle: Packet C

C

Glucose Metabolism

(Words)

Focus

: Strategies/Drugs for Treating

Diabetes

Cut out the words in each of

the boxes, along the solid

lines, and arrange them on the Puzzle templates.

Print

5

copies of this page and cut out the words for the various groups to work on the puzzle in packet

C

Glucose in Blood

Glucose in Blood

Insulin

Eat/drink Glucose

Glucagon

Glucosidase

Inhibitors

Acarbose

,

Miglitol

SGLT-2 Inhibitors

Canagliflozin

3.

Thiazolidinediones

Rosiglitazone

2. Sulfonylurea

Glipizide

1.

Biguanides

Metformin

DPP4 Inhibitors

Sitagliptin

,

Saxagliptin

GLP-1 Agonists

Liraglutide

Slide10

Glucose Homeostasis Puzzle: Packet C

2. Stages of puzzle building:Group 1 handles the puzzle with the template “Treating Type 1 DM”. The group also discusses the mechanism of actionGroup 2 handles the puzzle with the template “Treating Hypoglycemia” Group 3 handles the puzzle with the template “ Non-Insulin Treatments for Type 2 DM - 1”Group 4

handles the puzzle with the template “ Non-Insulin Treatments for Type 2 DM -

2”

Group

5

handles the puzzle with the template “ Non-Insulin Treatments for Type 2 DM

– 3”

Glucose Metabolism(Steps)

C

Slide11

Glucose in Blood

Store as GlycogenProvide energy

Glucose in Cells

Glucose uptake

Glycogen breakdown

Glucagon

Starch in food

Digestion

Glucose in Intestine

Absorption

Glucose in Kidney

Filtration

Reabsorption

Undigested/unabsorbed glucose to Feces

Excess glucose to Urine

Treating Type 1 DM

Insulin

C

Slide12

Glucose in Blood

Store as Glycogen

Provide energy

Glucose in Cells

Glucose uptake

Glycogen breakdown

Insulin

Low Blood Sugar

Pancreatic

a

-cells

Starch in food

Digestion

Glucose in Intestine

Absorption

Glucose in Kidney

Filtration

Reabsorption

Undigested/unabsorbed glucose to Feces

Excess glucose to Urine

+

-

DM Complications

Eat/drink Glucose

Treating Hypoglycemia

Glucagon

C

Slide13

Insulin

Glucose in BloodStore as Glycogen

Provide energy

Glucose in Cells

Glucose uptake

Glycogen breakdown

Glucagon

Starch in food

Digestion

Glucose in Intestine

Absorption

Glucose in Kidney

Filtration

Reabsorption

Undigested/unabsorbed glucose to Feces

Excess glucose to Urine

Glucosidase

Inhibitors

Acarbose

,

Miglitol

SGLT-2 Inhibitors

Canagliflozin

Non-Insulin Treatments for Type 2 DM - 1

C

Slide14

Insulin

Glucose in Blood

Store as Glycogen

Provide energy

Glucose in Cells

Glucose uptake

Glycogen breakdown

Glucagon

High Blood Sugar

Intestinal cells

Pancreatic

b

-cells

DPP-4

Starch in food

Digestion

Glucose in Intestine

Absorption

In

cretins

(GLP-1, GIP)

Glucose in Kidney

Filtration

Reabsorption

Undigested/unabsorbed glucose to Feces

Excess glucose to Urine

Proteolysis

+

-

-

DM Drugs:

In

cretin

related

DPP4 Inhibitors

Sitagliptin

,

Saxagliptin

Non-Insulin Treatments for Type 2 DM - 2

C

GLP-1 Agonists

Liraglutide

Slide15

3.

ThiazolidinedionesRosiglitazone2. SulfonylureaGlipizide

Insulin

Glucose in Blood

Store as Glycogen

Provide energy

Glucose in Cells

Glucose uptake

Glycogen breakdown

Glucagon

High Blood Sugar

Intestinal cells

Pancreatic

b

-cells

DPP-4

Starch in food

Digestion

Glucose in Intestine

Absorption

In

cretins

(GLP-1, GIP)

Glucose in Kidney

Filtration

Reabsorption

Undigested/unabsorbed glucose to Feces

Excess glucose to Urine

Proteolysis

+

-

-

DM Drugs:

First line of treatment

1.

Biguanides

Metformin

Non-Insulin Treatments for Type 2 DM - 3

C