Packets Included in this Puzzle A Glucose Metabolism and Cause of Diabetes Types1 and 2 B T he Physiology of Hypoglycemia and Hyperglycemia and Possible points of Diabetes Treatments ID: 912841
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Slide1
Glucose Homeostasis: In Health, Disease and With Treatment
Packets Included in this Puzzle:A. Glucose Metabolism and Cause of Diabetes Types1 and 2B. The Physiology of Hypoglycemia and Hyperglycemia; and Possible points of Diabetes Treatments C. Strategies/Drugs for Treating Diabetes (Types 1 and 2)
Slide2Glucose in Blood
Store as GlycogenProvide energy
Glucose in Cells
Insulin
Glucagon
Starch in food
Glucose in Intestine
Glucose in Kidney
Focus:
Glucose Metabolism Overview and Cause of Diabetes
Types 1
and 2
Cut out the words in each of the boxes, along the solid lines, and arrange them on the Glucose Metabolism Puzzle template so that they represent key steps in Glucose MetabolismCut out the red Type 1 and 2 DM boxes as well as the 2 red X on this page and place them on the Glucose Metabolism assembled puzzle showing where/what is missing or non-functional in the case of Type 1 and Type 2 DM
A
Type 2 DM
Type 1 DM
Glucose Metabolism
(Words)
Glucose Homeostasis Puzzle: Packet
A
Slide3Glucose in Blood
Store as Glycogen
Provide energy
Glucose in Cells
Glucose uptake
Glycogen breakdown
Insulin
Glucagon
Starch in food
Digestion
Glucose in Intestine
Absorption
Glucose in Kidney
Filtration
Reabsorption
Undigested/unabsorbed glucose to Feces
Excess glucose to Urine
Glucose Metabolism
(Template)
A
Slide4Glucose in Blood
Store as GlycogenProvide energy
Glucose in Cells
Insulin
Glucagon
Starch in food
Glucose in Intestine
Glucose in Kidney
Glucose Metabolism
(Words)
B
Glucose Homeostasis Puzzle: Packet B
Low Blood Sugar
Pancreatic
a
-cells+
-
High Blood Sugar
Intestinal cells
Pancreatic
b
-cells
DPP-4
In
cretins
(GLP-1, GIP)
+
-
-
Focus
: Glucose Metabolism during Hypoglycemia and Hyperglycemia
AND Possible processes and/or target for developing treatment strategies for
Diabetes
Cut out the words in each of
the boxes, along the solid
lines, and arrange them on the Puzzle templates.
Print 3 copies of this page and cut out the words for the various groups to work on the puzzle in packet B
Slide5Glucose Metabolism
(Steps)BGlucose Homeostasis Puzzle: Packet B
2. Stages
of puzzle building:
Group 1 handles the puzzle with the hypoglycemia template
Group 2 handles the puzzle with the hyperglycemia template
Groups 1 and 2 come together to assemble the hypo and hyperglycemia pathways on the Hypo- and Hyperglycemia template
Groups 1+2 or a different group should mark the possible points of DM treatment strategies. They present this to the class.
Slide6Glucose in Blood
Store as GlycogenProvide energy
Glucose in Cells
Glucose uptake
Glycogen breakdown
Insulin
Glucagon
Low Blood Sugar
Pancreatic
a
-cells
Starch in food
Digestion
Glucose in Intestine
Absorption
Glucose in Kidney
Filtration
Reabsorption
Undigested/unabsorbed glucose to Feces
Excess glucose to Urine
+
-
Hypoglycemia
B
Slide7Glucose in Blood
Store as Glycogen
Provide energy
Glucose in Cells
Glucose uptake
Glycogen breakdown
Insulin
Glucagon
High Blood Sugar
Intestinal cells
Pancreatic
b
-cells
DPP-4
Starch in food
Digestion
Glucose in Intestine
Absorption
In
cretins
(GLP-1, GIP)
Glucose in Kidney
Filtration
Reabsorption
Undigested/unabsorbed glucose to Feces
Excess glucose to Urine
Proteolysis
+
-
-
Hyperglycemia
B
Slide8Glucose in Blood
Store as Glycogen
Provide energy
Glucose in Cells
Glucose uptake
Glycogen breakdown
Insulin
Glucagon
High Blood Sugar
Intestinal cells
Pancreatic
b
-cells
DPP-4
Low Blood Sugar
Pancreatic
a
-cells
Starch in food
Digestion
Glucose in Intestine
Absorption
In
cretins
(GLP-1, GIP)
Glucose in Kidney
Filtration
Reabsorption
Undigested/unabsorbed glucose to Feces
Excess glucose to Urine
Proteolysis
+
-
-
+
-
Hypo- and Hyperglycemia
B
Slide9Glucose in Blood
Store as GlycogenProvide energy
Glucose in Cells
Insulin
Glucagon
Starch in food
Glucose in Intestine
Glucose in Kidney
Low Blood Sugar
Pancreatic
a
-cells
+
-
High Blood Sugar
Intestinal cells
Pancreatic
b-cells
DPP-4In
cretins (GLP-1, GIP)
+
-
-
Glucose Homeostasis Puzzle: Packet C
C
Glucose Metabolism
(Words)
Focus
: Strategies/Drugs for Treating
Diabetes
Cut out the words in each of
the boxes, along the solid
lines, and arrange them on the Puzzle templates.
Print
5
copies of this page and cut out the words for the various groups to work on the puzzle in packet
C
Glucose in Blood
Glucose in Blood
Insulin
Eat/drink Glucose
Glucagon
Glucosidase
Inhibitors
Acarbose
,
Miglitol
SGLT-2 Inhibitors
Canagliflozin
3.
Thiazolidinediones
Rosiglitazone
2. Sulfonylurea
Glipizide
1.
Biguanides
Metformin
DPP4 Inhibitors
Sitagliptin
,
Saxagliptin
GLP-1 Agonists
Liraglutide
Slide10Glucose Homeostasis Puzzle: Packet C
2. Stages of puzzle building:Group 1 handles the puzzle with the template “Treating Type 1 DM”. The group also discusses the mechanism of actionGroup 2 handles the puzzle with the template “Treating Hypoglycemia” Group 3 handles the puzzle with the template “ Non-Insulin Treatments for Type 2 DM - 1”Group 4
handles the puzzle with the template “ Non-Insulin Treatments for Type 2 DM -
2”
Group
5
handles the puzzle with the template “ Non-Insulin Treatments for Type 2 DM
– 3”
Glucose Metabolism(Steps)
C
Slide11Glucose in Blood
Store as GlycogenProvide energy
Glucose in Cells
Glucose uptake
Glycogen breakdown
Glucagon
Starch in food
Digestion
Glucose in Intestine
Absorption
Glucose in Kidney
Filtration
Reabsorption
Undigested/unabsorbed glucose to Feces
Excess glucose to Urine
Treating Type 1 DM
Insulin
C
Slide12Glucose in Blood
Store as Glycogen
Provide energy
Glucose in Cells
Glucose uptake
Glycogen breakdown
Insulin
Low Blood Sugar
Pancreatic
a
-cells
Starch in food
Digestion
Glucose in Intestine
Absorption
Glucose in Kidney
Filtration
Reabsorption
Undigested/unabsorbed glucose to Feces
Excess glucose to Urine
+
-
DM Complications
Eat/drink Glucose
Treating Hypoglycemia
Glucagon
C
Slide13Insulin
Glucose in BloodStore as Glycogen
Provide energy
Glucose in Cells
Glucose uptake
Glycogen breakdown
Glucagon
Starch in food
Digestion
Glucose in Intestine
Absorption
Glucose in Kidney
Filtration
Reabsorption
Undigested/unabsorbed glucose to Feces
Excess glucose to Urine
Glucosidase
Inhibitors
Acarbose
,
Miglitol
SGLT-2 Inhibitors
Canagliflozin
Non-Insulin Treatments for Type 2 DM - 1
C
Slide14Insulin
Glucose in Blood
Store as Glycogen
Provide energy
Glucose in Cells
Glucose uptake
Glycogen breakdown
Glucagon
High Blood Sugar
Intestinal cells
Pancreatic
b
-cells
DPP-4
Starch in food
Digestion
Glucose in Intestine
Absorption
In
cretins
(GLP-1, GIP)
Glucose in Kidney
Filtration
Reabsorption
Undigested/unabsorbed glucose to Feces
Excess glucose to Urine
Proteolysis
+
-
-
DM Drugs:
In
cretin
related
DPP4 Inhibitors
Sitagliptin
,
Saxagliptin
Non-Insulin Treatments for Type 2 DM - 2
C
GLP-1 Agonists
Liraglutide
Slide153.
ThiazolidinedionesRosiglitazone2. SulfonylureaGlipizide
Insulin
Glucose in Blood
Store as Glycogen
Provide energy
Glucose in Cells
Glucose uptake
Glycogen breakdown
Glucagon
High Blood Sugar
Intestinal cells
Pancreatic
b
-cells
DPP-4
Starch in food
Digestion
Glucose in Intestine
Absorption
In
cretins
(GLP-1, GIP)
Glucose in Kidney
Filtration
Reabsorption
Undigested/unabsorbed glucose to Feces
Excess glucose to Urine
Proteolysis
+
-
-
DM Drugs:
First line of treatment
1.
Biguanides
Metformin
Non-Insulin Treatments for Type 2 DM - 3
C