PPT-Epigenetic regulation of the IGF2 /H19 gene cluster.

Prospects for novel therapeutic traits Wilhelm Engström Professor of G eneral Pathology Uppsala Presentation 28 October 2014 The IGF system IGF2H19 domain IGF2 is parentally. Lamarck Revisited. Lamarck was incorrect in thinking that the inheritance of acquired characters is the main mechanism of evolution. However, we now know that the inheritance of acquired characters . . 19. . –. . Epigenomics. – Plants. . BIOL 5190/6190 Cellular & Molecular . Singal. Transduction. Prepared by Bob Locy. Last modified -13F. Epigenetics. – . Stable, but expression-related changes in gene function. . regulation. of the IGF2 /H19 gene cluster. . Prospects. for . novel. . therapeutic. . traits. Wilhelm Engström. Professor of . G. eneral . Pathology. Uppsala. Presentation 28 . October. 2014. Ivana de la Serna. Block Health Science 388. 383-4111. ivana.delaserna@utoledo.edu. Outline. 1. . Epigenetics. -definition and overview. 2. DNA methylation/. hydroxymethylation. 3. . Histone. modifications. WHEN THE . ENVIRONMENT . MEETS . THE GENETIC!. Medicel. Meeting . Palermo – . April. 26th 2014. WHAT WE KNOW:. CD. . prevalence. . is. . increasing. at . unexpected. rate in the last 20 . years. Using Probabilistic Graphical Models. Jianlin Cheng, PhD. University of Missouri. 2009. Bayesian Network Software. http://www.cs.ubc.ca/~murphyk/Software/BNT/bnsoft.html. Demo. Research in molecular biology is . Draw 8 boxes on your paper. Gene regulation accounts for some of the phenotypic differences between organisms with similar genes.. 2005-2006. Gene regulation in bacteria. Control of gene expression enables individual bacteria to adjust their metabolism to environmental change. An Data . Analysis . Activity. . for Students. . This . teacher slide set was . created by Dana Haine, MS, of the UNC . Superfund Research Program, . which is funded by the National Institute of Environmental Health Sciences (P42ES005948. Kalsi . Heimdal. Background. What is epigenetics?. What is an epigenetic modification?. How could it help with cancer therapy?. 2. Acute Myeloid Leukemia (AML). 3. Most common type of acute leukemia.. by. . methylation. . and. . acetylation. Epigenetics - possible definition(s) . Epigenetics. . is. . the. . study. . of. . how. . your. . behavior. . and. . environment. . can. . cause. Your Destiny. Central Dogma . Flow of genetic information in cell. Genetics vs. Epigenetics. Humans . 250. different . cell types. .. contain exact same DNA & same order. Initially a . sigmoid cell . One twin is large . at birth and has an. enlarged tongue and hypoglycemia. . The other twin appears normal.. . What could. be causing . these profound clinical differences between 2 infants who are. JABLONKA & LAMB: CHANGING CONCEPT OF EPIGENETICSment. We will then consider the practical importance of epigenetics in med-icine, agriculture, and ecology and, finally, look at the implications thatre AP Bio – Ch. 16-21. Unit 6 – Overview. Ch. 16 – The Molecular Basis of Inheritance (DNA). Ch. 17 – Gene Expression: From Gene to Protein. Ch. 18 – Regulation of Gene Expression. Ch. . 19 . – .