PPT-Development of morphine analogue

The Opium Analgesics Variation of subtituen Drug extension Simplification Rigdification History of opium we are now going look in detail at one of the oldest fields in medicinal chemistry It is. Andrea Terrell, PhD, DABCC. Chief Scientific Officer. AIT Laboratories. Indianapolis, IN. Prescription Drug Abuse. >125 . million ED visits in . 2011, 2.5 . million . (2.0%) . drug misuse or abuse related. Digital. . Migration. . and. . Spectrum. . Policy. . Summit. . Russell Southwood. Balancing Act. www.balancingact-africa.com. Snapshot of Progress of Analogue to Digital Migration in Africa: Outcome of ATU Survey. (PCM and DM). 1. The advantages offered by digital modulation . Performance . Digital pulse modulation permits the use of regenerative repeaters, when placed along the transmission path at short enough distances, can practically eliminate the degrading effects of channel noise and signal distortion. . . intro, . 7.1 natural analogues, . 7.2 constructed analogues (CA). , . 7.3 . specification . by CA. 7.4 . global . SST forecasts, . 7.5 . short range/dispersion, . 7.6 . growing . modes.  . In 1999 the earth’s atmosphere was gearing up for a special event. Towards the end of July, the 500mb flow in the . Precursor is formed by combining two C. 6. C. 2. units, both originating from tyrosine. Focus: . pieces/precursors. key assembly steps. structure-activity. physiological interactions. First . methylation. Distinction between analogue and discrete processes and quantities. Conversion of analogue quantities to digital form. Using sampling . techniques. Storage units. . Digital Data . Digital data . is represented by . – Beyond the limitations of analogue and digital –. Alexander Cartellieri. Head of Customer Relations and Sales. CONPRINTA Printing Technology. CONPRINTA …. … . is well established through its successful Belt Printing . The term narcotic . is used for the sedative agent, For pain control medications of both narcotic and non-narcotic varieties.. Today, the term "narcotic" refers . to. substances.  that bind to . opioid. Elizabeth Whiteman M.D.. Goals and objectives. Understand appropriate opioid use for pain. Understand side effects of opioids. Learn to treat and prevent side effects. Routes of administration. Equianalgesic dosing. Occurrence:. Opium is the air-dried . milky . exudate. , or latex, obtained by incising the mature unripe capsules of the . opium poppy. . Papaver. . somniferum. (Fam. . Papaveraceae. ). . Sources:. 1. *. Dean Forshaw. , . T. Affolder, G. . Casse. , I. Tsurin, M. Wormald. University of Liverpool. 18. th. . RD50 Workshop – . Liverpool, 23-25 May 2011. Outline. 2. 18. th. . RD50 Workshop – . M.Ed. Pharmacokinetics. Speed of onset is faster with increased lipid solubility. Morphine:. Relatively low lipid solubility. Only 10-20% un-ionized at physiologic pH so doesn’t diffuse into tissues quickly. 5. Quinoline. alkaloids. Alkaloids containing . quinoline. as their basic nucleus include those obtained from cinchona bark (. Cinchona . succirubra. ) ( quinine, . quinidine. , . cinchonine. , and . Chris Onof. 1. , Yuting Chen. 1. , Li-Pen Wang. 1,2. , Amy Jones. 3. , and Susana Ochoa Rodriguez. 4. 1. Dept. of Civil and Environmental Engineering, Imperial College London, London, United Kingdom.