PPT-Lecture 5: Chromosomes, linkage and genetic maps

Genetics Pedagogies Project Annie Jamieson AKJamiesonleedsacuk Human karyotype Source httpwwwgenomegovglossaryresourceskaryotypepdf Sex chromosomes Autosomes Homologous chromosomes. HapMap. Peter Castaldi. January 29, 2013. Objectives. Introduce the concept of linkage disequilibrium (LD). Describe how the . HapMap. project provides publically available information on genetic variation and LD structure. Prepared by -. RAKESH CHOUDHARY. M.Sc.(AGRI) . GENETICS AND PLANT BREEDING . . WELCOME. Linkage and Chromosome. Mapping . Linkage and Chromosome. Mapping . Genetic linkage was first discovered by the . Trey Ideker. Genetics 101:. The Basis of Genome Association. Selected slides courtesy. Jim . Stankovich. and Hector . Corrada. Bravo. Review of Mendelian genetics. Gregor Mendel analyzed the patterns of inheritance of seven pairs of contrasting traits in the domestic pea plant. As an example pair:. HORT6033. Molecular . Plant . B. reeding. Instructor: Ainong . Shi. HORT6033 web site: . http://comp.uark.edu/~ashi/MB. . Fall 2014 HORT6033. Molecular Plant Breeding. Lecture 9 . (09/22/2014). Genetic map construction.  . I. Genetic, Cytological, and Physical Maps. II. Human Genome Project. A. . Goals of the Human Genome Project. B. . Public and Private First Drafts of the Human Genome Sequence. R. r. Source: plant-genetics.kais.kyoto-u.ac.jp. ATGGGCACTGCCACT. A chromosome is a single DNA molecule complexed with histone proteins. DNA is highly compacted: DNA + histone proteins = . chromatin. KEY CONCEPT . Genes can be mapped to specific locations on chromosomes.. . Discovery education. http://app.discoveryeducation.com/player/?assetGuid=4FAF6391-FD45-4249-A188-66C3DF02770F&fromMyDe=0&isPrinterFriendly=0&provider=&isLessonFromHealth=0&productcode=US&isAssigned=false&includeHeader=YES&homeworkGuid. Independent Assortment & Linkage. Genetic & Physical Maps. Lecture 1- Genetics. Madan K. Bhattacharyya, Ph.D.. Professor, Iowa State University. Adjunct Prof., Assam Agricultural University. mbhattac@iastate.edu. ). The . chemical and engineering basis of . heredity. Dr. . israa. . hussein. . hamzah. email: . esraa_hassan17@yahoo.com. szsh@uomustansiriyah.edu.iq. Reference book. : . genetic (Conceptual-Approach) fourth edition (2010). 1 Genetic and Physical MappingThe ultimate goal of mapping is to identify the gene(s) responsible for a given phenotype or the mutation responsible for a specific variant.The initial steps in mapping Maps 1
Distance measured in Morgans (M) 2
Distance measured in Morgans (M) Physical MapsActual structure of genetic materialAt highest level DNA sequenceDistance measured in 10bp (Mbp) Genetic and cation of marker-trait associations, mapping Quantitative Trait Loci (QTL), candidate gene identi cation, basis for high-resolution genetic ne-mapping, which provide powerful tools for genetic anal Discovery. Genetic linkage was first discovered by the British. . geneticists William Bateson, Edith Rebecca Saunders and Reginald Punnett. . shortly after Mendel's laws were rediscovered. The understanding of genetic linkage was expanded by the work of Thomas Hunt Morgan. . The Basis of Genome Association. Selected slides courtesy. Jim . Stankovich. and Hector . Corrada. Bravo. Review of Mendelian genetics. Gregor Mendel analyzed the patterns of inheritance of seven pairs of contrasting traits in the domestic pea plant. As an example pair:.