PPT-Lecture 5: Chromosomes, linkage and genetic maps

Genetics Pedagogies Project Annie Jamieson AKJamiesonleedsacuk Human karyotype Source httpwwwgenomegovglossaryresourceskaryotypepdf Sex chromosomes Autosomes Homologous chromosomes. HapMap. Peter Castaldi. January 29, 2013. Objectives. Introduce the concept of linkage disequilibrium (LD). Describe how the . HapMap. project provides publically available information on genetic variation and LD structure. Recombination. Missouri University of Science and Technology. Recombination explores the search space. Classic Recombination. N-point crossover. Uniform. Limitation. Disrupting good partial solutions via crossover is problematic. Trey Ideker. Genetics 101:. The Basis of Genome Association. Selected slides courtesy. Jim . Stankovich. and Hector . Corrada. Bravo. Review of Mendelian genetics. Gregor Mendel analyzed the patterns of inheritance of seven pairs of contrasting traits in the domestic pea plant. As an example pair:. HORT6033. Molecular . Plant . B. reeding. Instructor: Ainong . Shi. HORT6033 web site: . http://comp.uark.edu/~ashi/MB. . Fall 2014 HORT6033. Molecular Plant Breeding. Lecture 9 . (09/22/2014). Genetic map construction. Chromosome mapping by recombination . Meiosis is the basis of transmission genetics. The recombination that occurs during meiosis (in heterozygotes) generates data that are a useful tool for making linkage maps. Professor . Dept of Epidemiology and. Genetic Epidemiology Research Institute. School . of . Medicine. University of . California Irvine. . Seattle, WA. Family Studies: Family Health History, Segregation and Linkage Analysis. KEY CONCEPT . Genes can be mapped to specific locations on chromosomes.. . Discovery education. http://app.discoveryeducation.com/player/?assetGuid=4FAF6391-FD45-4249-A188-66C3DF02770F&fromMyDe=0&isPrinterFriendly=0&provider=&isLessonFromHealth=0&productcode=US&isAssigned=false&includeHeader=YES&homeworkGuid. SUTTON’S VIEW ON LINKAGE:. Sutton predicted that the chromosomes are the bearers of the units of heredity or genes and since the number of hereditary units is much larger than the number of chromosomes, therefore each chromosome must contain a number of genes.. ). The . chemical and engineering basis of . heredity. Dr. . israa. . hussein. . hamzah. email: . esraa_hassan17@yahoo.com. szsh@uomustansiriyah.edu.iq. Reference book. : . genetic (Conceptual-Approach) fourth edition (2010). 1 Genetic and Physical MappingThe ultimate goal of mapping is to identify the gene(s) responsible for a given phenotype or the mutation responsible for a specific variant.The initial steps in mapping cation of marker-trait associations, mapping Quantitative Trait Loci (QTL), candidate gene identi cation, basis for high-resolution genetic ne-mapping, which provide powerful tools for genetic anal Discovery. Genetic linkage was first discovered by the British. . geneticists William Bateson, Edith Rebecca Saunders and Reginald Punnett. . shortly after Mendel's laws were rediscovered. The understanding of genetic linkage was expanded by the work of Thomas Hunt Morgan. . They are also called as mega chromosomes. . These chromosomes are very long and thick in appearance during metaphase than normal chromosomes.. Hence they are called as Giant chromosomes.. The Giant chromosomes are of two types-. M.Sc. II semester. Paper –III, Unit 4. By . Dr. . Tulika. . Mishra. LINKAGE. Genetic linkage. is the tendency of . DNA sequences. that are close together on a . chromosome. to be inherited together during the .