PPT-Linkage and Crossing Over

MSc II semester Paper III Unit 4 By Dr Tulika Mishra LINKAGE Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the . HapMap. Peter Castaldi. January 29, 2013. Objectives. Introduce the concept of linkage disequilibrium (LD). Describe how the . HapMap. project provides publically available information on genetic variation and LD structure. Chromosome mapping by recombination . Meiosis is the basis of transmission genetics. The recombination that occurs during meiosis (in heterozygotes) generates data that are a useful tool for making linkage maps. Key Reference. Li, Q., and R. L. Wu, 2009 A . multilocus. model for constructing a linkage disequilibrium map in human populations. . Statistical Applications in Genetics and Molecular Biology . 8 (1): Article 18.. What are your choices?. Who can help?. ALABAMA DEPARTMENT OF REHABILITATION SERVICES (ADRS) . . VOCATIONAL REHABILITATION PROGRAM: . READI-Net. ……resources . to help with compliance & linkage agreements. Connecting system components. Allows configuring automatic actions. Triggering outputs based on specific inputs. Used for removing human reliance. Also used as backup to normal operations. Basic concepts. Key Reference. Li, Q., and R. L. Wu, 2009 A . multilocus. model for constructing a linkage disequilibrium map in human populations. . Statistical Applications in Genetics and Molecular Biology . 8 (1): Article 18.. Chromosome mapping by recombination . Meiosis is the basis of transmission genetics. The recombination that occurs during meiosis (in heterozygotes) generates data that are a useful tool for making linkage maps. the Red Sea. God’s guidance and presence . Crossing . the Red Sea. God . fights for . us. God’s guidance and presence . Crossing . the Red Sea. God defeats our enemy. God . fights for . us. God’s guidance and presence . Crossing of a cheque Crossing prevents fraud and wrong payments. It means “Drawing Two Parallel Lines” across the face of the cheque . Thus crossing is necessary in order to have safety. Meaning Patterns of inheritance. Homework - Multiple Alleles: Hierarchy. Sometimes there are more than 3 alleles, occurring in a dominance hierarchy. Coat Colour in Rabbits. Agouti coat is dominant to Chinchilla coat, which is dominant to Himalayan coat, which is dominant to Albino coat. PBG 430. Linkage. Linkage is the non-random . association. of two or more phenotypes or sequences in a population (genes/sequences are (almost) always inherited together). Biological explanation for linkage: genes or sequences are closely located in the same chromosome. Crossing over . The term crossing over was coined by Morgan.. In crossing over , exchange the chromosomal parts or segments in the non-sister chromatids of homologous chromosomes. . In another words , . SUTTON’S VIEW ON LINKAGE:. Sutton predicted that the chromosomes are the bearers of the units of heredity or genes and since the number of hereditary units is much larger than the number of chromosomes, therefore each chromosome must contain a number of genes.. Commercial considerations relevant to TPP. 1. Geraldine Storton. Hospira. Pty Ltd. Overview. Who is . Hospira. ?. What is patent linkage?. Relative market sizes of TPP members. Patent linkage hypothetical financial analysis.