PPT-Linkage Mapping – Part 1

PBG 430 Linkage Linkage is the nonrandom association of two or more phenotypes or sequences in a population genessequences are almost always inherited together Biological explanation for linkage genes or sequences are closely located in the same chromosome. Key Reference. Li, Q., and R. L. Wu, 2009 A . multilocus. model for constructing a linkage disequilibrium map in human populations. . Statistical Applications in Genetics and Molecular Biology . 8 (1): Article 18.. Trey Ideker. Genetics 101:. The Basis of Genome Association. Selected slides courtesy. Jim . Stankovich. and Hector . Corrada. Bravo. Review of Mendelian genetics. Gregor Mendel analyzed the patterns of inheritance of seven pairs of contrasting traits in the domestic pea plant. As an example pair:. Key Reference. Li, Q., and R. L. Wu, 2009 A . multilocus. model for constructing a linkage disequilibrium map in human populations. . Statistical Applications in Genetics and Molecular Biology . 8 (1): Article 18.. HORT6033. Molecular . Plant . B. reeding. Instructor: Ainong . Shi. HORT6033 web site: . http://comp.uark.edu/~ashi/MB. . Fall 2014 HORT6033. Molecular Plant Breeding. Lecture 9 . (09/22/2014). Genetic map construction. . Egusquiza. D145 Presentation. January 12, 2017. What is genome mapping?. http://www.yourgenome.org/facts/how-do-you-map-a-genome. The use of various methods to determine the locus of a genetic landmarks (genes, regulatory sites, etc.) and the relative distances between genetic landmarks in the genome. Inheritance of genes that are on different chromosomes vs. close together on the same chromosome. When genes are closely linked on the same chromosome, how does this affect their segregation pattern?. . Egusquiza. D145 Presentation. January 12, 2017. What is genome mapping?. http://www.yourgenome.org/facts/how-do-you-map-a-genome. The use of various methods to determine the locus of a genetic landmarks (genes, regulatory sites, etc.) and the relative distances between genetic landmarks in the genome. Kernel Composition in the . Nested Association Mapping (NAM) Population. Sherry Flint-Garcia. USDA-ARS Columbia, MO. Outline. Development of NAM Population. Kernel Composition. Joint Linkage Mapping. Kernel Composition in the . Nested Association Mapping (NAM) Population. Sherry Flint-Garcia. USDA-ARS Columbia, MO. Outline. Development of NAM Population. Kernel Composition. Joint Linkage Mapping. petercelec@gmail.com. www.imbm.sk. Linus. . Carl. . Pauling. (1901 – 1994). Nobel. . prize. 1954 – . Chemistry. 1962 – Peace. Francis. . Crick. (1916 – 2004). Nobel. . p. rize. 1962 – . The . process . of constructing . linkage . maps . and . conducting . QTL . analysis . i.e. . to . identify genomic regions . associated . with . traits . is . known as . QTL. . mapping. .. Identification . 1.38 pairs of homosexual brothers that demonstrated possible maternal inheritance.Pedigree and linkage analysis to locate possible loci on the X chromosome responsible for inheritance ofhomosexuality. 1 Genetic and Physical MappingThe ultimate goal of mapping is to identify the gene(s) responsible for a given phenotype or the mutation responsible for a specific variant.The initial steps in mapping cation of marker-trait associations, mapping Quantitative Trait Loci (QTL), candidate gene identi cation, basis for high-resolution genetic ne-mapping, which provide powerful tools for genetic anal