PPT-Linkage & Recombination

Discovery Genetic linkage was first discovered by the British geneticists William Bateson Edith Rebecca Saunders and Reginald Punnett shortly after Mendels laws were rediscovered The understanding of genetic linkage was expanded by the work of Thomas Hunt Morgan . Chromosome mapping by recombination . Meiosis is the basis of transmission genetics. The recombination that occurs during meiosis (in heterozygotes) generates data that are a useful tool for making linkage maps. Prepared by -. RAKESH CHOUDHARY. M.Sc.(AGRI) . GENETICS AND PLANT BREEDING . . WELCOME. Linkage and Chromosome. Mapping . Linkage and Chromosome. Mapping . Genetic linkage was first discovered by the . Recombination. Missouri University of Science and Technology. Recombination explores the search space. Classic Recombination. N-point crossover. Uniform. Limitation. Disrupting good partial solutions via crossover is problematic. Trey Ideker. Genetics 101:. The Basis of Genome Association. Selected slides courtesy. Jim . Stankovich. and Hector . Corrada. Bravo. Review of Mendelian genetics. Gregor Mendel analyzed the patterns of inheritance of seven pairs of contrasting traits in the domestic pea plant. As an example pair:. HORT6033. Molecular . Plant . B. reeding. Instructor: Ainong . Shi. HORT6033 web site: . http://comp.uark.edu/~ashi/MB. . Fall 2014 HORT6033. Molecular Plant Breeding. Lecture 9 . (09/22/2014). Genetic map construction. Chromosome mapping by recombination . Meiosis is the basis of transmission genetics. The recombination that occurs during meiosis (in heterozygotes) generates data that are a useful tool for making linkage maps. Inheritance of genes that are on different chromosomes vs. close together on the same chromosome. When genes are closely linked on the same chromosome, how does this affect their segregation pattern?. Linkage. One of the main observations from Mendel was independent assortment – alleles of different genes will get assorted (mixed up) independently of one another. We already showed that the genes are carried by the linear chromosomes. Mendel’s traits showed two distinct forms . Most genes do not exhibit simple inheritance. Genotypic ratios persist but phenotypic ratios may vary due to “outside-the-gene” influences including . R. r. Source: plant-genetics.kais.kyoto-u.ac.jp. ATGGGCACTGCCACT. A chromosome is a single DNA molecule complexed with histone proteins. DNA is highly compacted: DNA + histone proteins = . chromatin. PBG 430. Linkage. Linkage is the non-random . association. of two or more phenotypes or sequences in a population (genes/sequences are (almost) always inherited together). Biological explanation for linkage: genes or sequences are closely located in the same chromosome. Independent Assortment & Linkage. Genetic & Physical Maps. Lecture 1- Genetics. Madan K. Bhattacharyya, Ph.D.. Professor, Iowa State University. Adjunct Prof., Assam Agricultural University. mbhattac@iastate.edu. The Basis of Genome Association. Selected slides courtesy. Jim . Stankovich. and Hector . Corrada. Bravo. Review of Mendelian genetics. Gregor Mendel analyzed the patterns of inheritance of seven pairs of contrasting traits in the domestic pea plant. As an example pair:. Linkage and linkage disequilibrium. Demonstration of software (. FamLink. ). Tutorials and exercises.  . Statistical inference for expanded marker panels (Part 2: “Large” panels) (10-12am). Technologies.