IMPORTANT OPHTHALMIC TUMOURS - PowerPoint Presentation

 IMPORTANT OPHTHALMIC TUMOURS
 IMPORTANT OPHTHALMIC TUMOURS

IMPORTANT OPHTHALMIC TUMOURS - Description


MICHAEL E GIBLIN FRANZCO ASIA PACIFIC SOCIETY OF OCULAR ONCOLOGY AND PATHOLOGY Uveal melanoma Iris melanoma Large Diffuse Rapid growth Hyphaema Refractory glaucoma Subjacent ciliary body involvement ID: 776701 Download Presentation

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treatment options melanoma observationtttlocal treatment options melanoma observationtttlocal choroidal base plaque retinoblastoma thickness metastasis resection equator resectionradioactive therapy ttt

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Presentation on theme: " IMPORTANT OPHTHALMIC TUMOURS"— Presentation transcript


Slide1

IMPORTANT OPHTHALMIC TUMOURS

MICHAEL E GIBLIN FRANZCO

ASIA PACIFIC SOCIETY OF OCULAR ONCOLOGY AND PATHOLOGY

Slide2

Uveal melanoma

Slide3

Iris melanoma

LargeDiffuseRapid growthHyphaemaRefractory glaucomaSubjacent ciliary body involvement

Slide4

Symptoms

Thickness > 2mm

Orange pigment (lipofuscin)GrowthSubretinal fluidPeripapillary location

Choroidal

naevus versus melanoma

Slide5

MM treatment options

ObservationTranspupillary laser thermotherapy (TTT)

Posterior pole

Thickness < 3.5mm

Slide6

Slide7

Melanoma treatment options

ObservationTTTLocal resection

Base < 10mmAnterior to equator

Slide8

MM treatment options

ObservationTTTLocal resectionRadioactive plaque therapy

Base <15(18)mm

Thickness < 8mm

Slide9

Ruthenium 106

Iodine 125

Slide10

MM treatment options

Observation

TTT

Local resection

Radioactive plaque therapy

Proton beam/helium ion irradiation

Stereotactic R/T; LINAC/gamma knife

Slide11

MM treatment options

ObservationTTTLocal resectionRadioactive plaque therapyProton beam/helium ion irradiationSterertactic radiotherapyEnucleation

Base > 18mm

Slide12

BAP1

BAP1 = BRCA Associated Protein 1

Recessive cancer suppression gene

Located on 3p21.1

Associated with monosomy 3

In

activating mutation leads to liver metastasis

Slide13

Circumscribed

choroidal

haemangioma

Slide14

High internal reflectivity

Slide15

Metastatic tumours

May be multifocal

Characteristically posterior to equator

Usually

amelanotic

Leopard-skin RPE spotting

Sub-retinal fluid if active

Treat if sight affected

Lung ca.

Choroidal

metastasis may precede detection of primary

Slide16

Slide17

Retinoblastoma

Slide18

Retinoblastoma

Aim for earlier detection

Chemotherapy mainstay of treatment for hereditary retinoblastoma

Incresing

role for

intraarterial

chemotherapy

Shom More....