Plt00001 Plt00001 P08 11 MPI Control Hp Hm Hh 00 25 50 75 100 125 6 MPI Control Hp Hm Hh HmHp HhHp 00 25 50 75 100 125 B Figure 1 A Ifn Sham ID: 1042260
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1. HmHpHhHpHAI ScoresP=0.01P<0.0001P<0.0001P=0.811 MPIControlHpHmHh0.02.55.07.510.012.56 MPIControlHpHmHhHmHpHhHp0.02.55.07.510.012.5BFigure 1A
2. Ifn-ShamHpHmHmHpHhHhHp-10-50510152070758085P<0.0001P<0.0001Il-1ShamHpHmHmHpHhHhHp-4-3-2-10123456P<0.0001P=0.076Tnf-ShamHpHmHmHpHhHhHp-1001020P<0.0001P<0.0001Figure 2************P<0.0001P<0.0001*******************P<0.0001
3. Il-17A6 MPIHAIP<0.0001, r2=0.92P=0.0018, r2=0.82HAIIl-17AGastric IL17A mRNA levelsFold change compared to sham controlCHpHmHpHhHpHmHh0255075100125150HbHpHb-106 MPI11 MPIP=0.2P=0.059P=0.018P=0.025P=0.0002P=0.018HpHmHpHhHpHmHbHpHbCHhAB11 MPIFigure 3*********************P=0.0031P=0.0011P<0.0001P<0.0001********
4. Figure 4*********P=0.0005P=0.019**********P=0.00156P=0.045P=0.0016 MPI11 MPI
5. HhHp-6HhHp-11HmHp-6HmHp-11Hp-6Hp-11100101102103104105106107108Numbers of gastric Hp per g mouse DNA#####Figure 5
6. Cecal colonization of Hh and HmHhHmHh-6Hh-11HhHp-6HhHp-11Hm-6Hm-11HmHp-6HmHp-11101102103104105106107108CecumFigure 6Gastric colonization of Hh and HmHh-6Hh-11HhHp-6HhHp-11Hm-6Hm-11HmHp-6HmHp-11100101102103104105106107108HhHmStomachAB
7. Hp infectionsAntigensAPCs (DC, Macrophages)Th17 PathwaysTreg cellsIntestineStomachTh1 Pathway+Hp Gastric pathologyHm or HbAttenuated Gastric pathologyHhTh17-AntigensHhTh17cellsHp sTreg cells+Aggravated or comparableGastric pathology PI iPI AIHp Figure 7