PPT-Hematopoietic Stem Cell Transplantation

Ivetta Danylesko MD Department of Bone Marrow Transplantation Chaim Sheba Medical Center Tel Hashomer History HSCT was first explored in humans in the 1950s and was based on observational studies in mice models which showed that infusion of healthy bone marrow components into a . Learning objectives. To understand the difference between allogeneic and autologous HSCT. To understand the types of and reasons for the different HSCT conditioning regimens. To recognise potential complications associated with HSCT. Location of Centers Participating. in the CIBMTR 2015. Annual Number of Transplant Recipients in the US by Transplant Type. Allogeneic Transplant Recipients in the US, by Donor Type. Cumulative Plot of Transplant Recipients in the US by Transplant Type. Transplantation . Apheresis and Mobilization . Donna . F. erguson, M.D.. July 16, 2015. History . Overview. Stem cell transplantation . HPC, Apheresis . HPC, Bone marrow . Autologous . Allogeneic . Donor and recipient . Present. . and. . Future. Mustafa CETIN. ,. . MD . December. ,. . 2016. Erciyes University BMT Center. KHUH . , Doctor . Education Program. Passweg . et al. . BMT Feb. . 2016. ASCT in . Europe (2014. Location of Centers Participating. in the CIBMTR 2014. Annual Number of Transplant Recipients in the US by Transplant Type. Transplant Recipients in the US, by Transplant and Donor Type. Cumulative Plot of Transplant Recipients in the US by Transplant Type. Location of Centers Participating. in the CIBMTR 2013. Transplant Activity in the US. Allogeneic Stem Cell Sources by Recipient Age. Autologous Stem Cell Sources by Recipient Age. Trends in Transplants. Ricerche. . Genetiche. e . Biomediche. (IRGB)/CNR. and . Humanitas Research Center. Pavia, . February. 29. th. , 2016. 1. Induced. . pluripotent. . stem. . (. iPS. ) . cells. iPSc. are . obtained by reprogramming . Current Positions:  Armand Quick – William Stapp Professor of Hematology , in the Department of Medicine in the Division of Hematology and Oncology  Se ction Head , Hematological Maligna At the end of this unit of study, the student should be able to:. Describe the basic concepts of cell differentiation and maturation.. Compare and contrast the categories of hematopoietic precursor cells: hematopoietic stem cells, hematopoietic progenitor cells, and maturing cells, including proliferation and differentiation potential, morphology, and population size.. A Pediatric Transplant Infectious Diseases Learning Module. Using the Modules. The modules are case-based, with decision points (branches) containing questions. Many questions don’t have right or wrong answers. Dr. Ali Khazaal Jumaa. F.I.B.M.S (Int. Medicine) , F.I.B.M.S (hematology). Definition :. Hematopoietic . stem cell transplantation (HSCT) involves the intravenous infusion of . autologous. or . allogeneic. BIOETHICS. STEM CELLS. A. . stem cell . is an immature cell capable of rapid division, self-renewal and development into specialized cells of the body.. Stem cells, having received signals from regulatory systems about some kind of “malfunction”, rush to the affected organ through the blood. Allografts. . transplantation of organs from one individual to another of the same species.. Rejection. is a complex phenomenon involving both cell- and antibody-mediated reactions that destroy the graft.. Def: the administration of hematopoietic stem cells from any source (ex: bone marrow, peripheral blood, umbilical cord blood) to reconstitute the bone marrow.. The Nobel Prize, 1990. E. Donnall Thomas .