PPT-CHROMOSOMAL ABERRATIONS Dr.H.B.Mahesha

Yuvarajas College University of Mysore Mysore 11 September 2020 1 wwwhbmaheshweeblycom Chromosomes have definite structure and organization which is normally constant from one cell division to next . Instituto de Oftalmología, Fundación Conde de Valenciana, I.A.P. .. Authors: Oscar Mac. ías Manuel, MD. Alejandro Navas Perez, MD. Coauthors: Enrique Graue, MD. Tito Ramírez Luquín, MD. Authors have no financial interest. Copy . Number Alterations for Risk Stratification in Chronic Lymphocytic Leukemia. Jane Houldsworth PhD*, Asha Guttapalli MS*, Xiao . Jie. Yan MD PhD. †. , Charles Ma PhD*, Weiyi Chen PhD*, . Sujata. A. .. L. Ponomarev. 1,. 3. , . K. George. 1,3. , . F. .. A. Cucinotta. 3. 1. USRA, 3600 Bay Area Blvd., Houston, TX 77058. 2. Wyle, 1290 Hercules Drive, Houston, 77058. 3. NASA JSC, Mail Code SK, 2101 NASA Parkway, Houston, TX 77058. Types . of Mutations | . Effects . of . Mutations. Learning Objectives. Identify different changes to DNA within both genes and chromosomes. Evaluate effects of changes to DNA on proteins produced and organisms’ overall survival. Mutations. Hollywood’s images of . mutation. Mutations. Actual Mutations . in fruit flies. What is a mutation?. A mutation is any change in a cell’s DNA. A mutation can occur in an individual gene. Dawn Adams. Cytogenetics. CDC’s 2003 Science Ambassador Program. Overview. I. Chromosomal Variations. A. Polyploidy. B. Aneuploidy. II. Syndromes resulting from Aneuploidy. A. Trisomy 13. B. Trisomy 18. Istanbul. . International. . Hospital. IVF . Center. Is . aneuploidy. . screening. an . efficient. . tool. in . embryo. . selection. ?. Best. . embryo. Symmetrical. . PNs. . with. . equal. Cytogenetics. CDC’s 2003 Science Ambassador Program. Chromosomal Karyotypes. Overview. I. Chromosomes. A. Definition. B. Structure. C. Identification. II. Karyotypes. A. Definition. Henry County Professional Learning High School Session II. Chromosomal Mutations. Deletion. – part of the chromosome is missing. Starts with breaks in the chromosome. Radiation, heat, viruses, chemicals, etc.. Karyotype. Human Chromosomes. Humans have . 46 . chromosomes arranged in . 23. pairs. Two . sex chromosomes. - determine an individual’s sex. Females . have two copies of the large X chromosome. Males have one X and a smaller Y chromosome. 12.1 Chromosomal Inheritance . 1. Genes are located on chromosomes; this is called the . chromosome theory of inheritance. .. 12.1 Chromosomal Inheritance. Chromosomes can be categorized as two types:. What if it’s NOT just the number?. Gene Mutations. Damaged Chromosomes . –. sometimes a portion of a gene or chromosome is lost or damaged during meiosis. Gene mutation. – a mutation that affects the gene. R. Selvi a , Govind Raghav Saranya a , Jyotsna Murthy b , Andrea Mary F a , Solomon F. D. Paul a CORRESPONDING AUTHOR : Ms. R. SELVI Lecturer, Department of Human Genetics, Sri Ramachandra Universit Francesca . Ballarini. e Mario P. . Carante. Università. . degli. . Studi. di Pavia, . Dipartimento. di . Fisica. INFN – . Sezione. di Pavia. francesca.ballarini@unipv.it. Workshop CTL Life .