PPT-Are ACE Inhibitors and Angiotensin Receptor Blockers associated with all-cause mortality

W Hinton 12 H DambhaMiller 3 MFeher 1 J Sheppard 1 MJoy 1 N Munro 24 S de Lusignan 15 1 Nuffield Department of Primary Care Health Sciences University of Oxford Oxford UK. Dr. . Naser. Ashraf . Department of Basic Medical Sciences . College of Medicine . Majmaah University . Objectives . List major drug groups used in treatment of heart failure . Explain mechanism of action of digitalis and its major effects . MARLON T. CO,MD. DISCLOSURE. Advisory board of Merck Philippines. Ps-DZ, 2009. Global Leading Risks for Death, 2010. Systolic blood pressure > 115 mmHg. Global Burden of Disease Study 2010 , . Lancet . Milton Packer, John J.V. McMurray, Akshay S. Desai, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Scott D. Solomon, Karl Swedberg and Michael R. Zile for the PARADIGM-HF Investigators and Committees. Hypertension. is defined as either a sustained . systolic. blood pressure of greater . > than . 140 mm Hg. or a sustained . diastolic. blood pressure of greater than . 90 mm Hg. .. Arterial blood pressure is directly proportional to . Dr.AZDAKI. . (cardiologist).  Initial . monotherapy. is successful in many patients with mild primary hypertension (formerly called "essential" hypertension). . However, single-drug therapy is unlikely to attain goal blood pressure in patients whose blood pressures are more than 20/10 mmHg above goal. . as antagonists . for AT. 2. . receptors to decrease . bradykinin. production . Tina . Stutzman. Nick Swenson. 20.109. May 12, 2010. Hypertension is related to renal and cardiac . f. ailure . Hypertension (high blood pressure). ACEIs are among the most widely prescribed antihypertensive drugs. .. In general, these . drugs are . well absorbed from the GI tract, reaching peak . serum conc. within . 1 to 4 hours. . These drugs are . Cause . of. hypertension. Why and when to treat?. How to treat?. Etiopathogenesis of essential hypertension (EH). Cause of EH is abnormality of blood pressure regulation at different levels:. 1) CNS cortex regulation. Lec. . . Sura. . abbas. . Medicine ward. Quick revision. The most common causes of heart failure are coronary artery disease (CAD), hypertension, and dilated cardiomyopathy. . The sympathetic nervous system and the renin-angiotensin. An individual patient level analysis of double-blind randomised trials. Dipak Kotecha, MBChB PhD MRCP FESC FHEA. on behalf of the . . Beta-blockers in Heart Failure Collaborative Group. Douglas Altman. %). Clinicians should aim to screen for and . treat comorbidities . such as hypertension, CAD, diabetes mellitus, anemia, and sleep-disordered breathing, as these conditions tend to exacerbate HF. . HF . BP. Congest-ion*. Haemo. -globin. K. +. GFR. BNP#. Echo. Diuretics. . . . . . . . ACEi/ARB. . . . I. ARNI. . . . I. I. β. -Blocker. R?. . R?. . I. MRA. . when resting systolic blood pressure exceeds . 130 or diastolic . blood pressure exceeds 80 mm . Hg.. Even stage 1 hypertension (<140/90. ) has been reported to increase the risk of end-organ damage. system. Dr Nish . Arulkumaran. SpR. and Clinical Research fellow. Imperial College London. GEP – Renal, . Feb2012. Systolic and Diastolic pressure. Heart cycle = systole and diastole. Systole = ventricular contraction = ejection .