PPT-Blood pressure and the renin-angiotensin

system Dr Nish Arulkumaran SpR and Clinical Research fellow Imperial College London GEP Renal Feb2012 Systolic and Diastolic pressure Heart cycle systole and diastole Systole ventricular contraction ejection . Mike Clark, M.D.. MAP = CO x SVR. CO = HR x SV. SV = EDV – ESV . (EDV concerned with blood volume and ESV concerned more with inotropic effect). SVR = ∑R₁ + R₂ + 1/R₃ + 1/R₄ …... R = 8ŋL/∏r⁴. Robyn Dane and Katy Davidson. How do you calculate MAP?. MAP = CO x SVR . MAP . = (2DBP + SBP)/. 3. How do you calculate pulse pressure?. Difference between diastolic and systolic pressures. PP = SBP - DBP. Drugs Acting on the Renin-Angiotensin-Aldosterone System. Physiology of the renin-angiotensin-aldosterone system. Angiotensin-converting enzyme inhibitors. Angiotensin II receptor blockers. Aldosterone antagonists. Kelsey Davis, Courtney Getchell, Robert . Kolar. Introduction. We will be covering the topic of . prodrugs. , specifically a hypertension medication . Olmesartan. .. An introduction to . prodrugs. and what they are used for.. Blood Pressure. Dr . K. hwaja Amir. Assistant Professor. Objectives . By the end of this session, the student should be able to:. Outline the different mechanisms involved in regulation of ABP.. Discuss the role of reflexes especially baroreceptor reflex . Blood Pressure Control. Widespread Control – Control all over the body. A. Nervous System. B. Hormones. Local Control – Control of certain organs. MAP = CO x SVR. CO = HR x SV. SV = EDV – ESV . Blood Pressure Control Simplified Version Blood Pressure Control Widespread Control – Control all over the body A. Nervous System B. Hormones Local Control – Control of certain organs MAP = CO x SVR HYPERTENSION. BLOOD pressure that is above normal for sustained period . .. . Most common health problem In adults and the leading cause of cardiovascular . disorder.. Hypertension is the term used to describe high blood pressure. . Irbesartan. . for control of . Hypertension. Valentina. . Forni. , . Gregoire. . Wuerzner. , . Menno . Pruijm. , . Michel . Burnier. Service of Nephrology and Hypertension, Department of Medicine, Centre . System. The Cardiovascular Continuum . Myocardial Infarction. Heart Failure. End-Stage Heart Disease. Plaque Rupture. Risk Factors. Hypertension. Hyperlipidemia. Diabetes. Atherosclerosis. Endothelial Dysfunction. . Fuad. بورد عراقي (دكتوراه) في الطب الباطني. بورد عربي (دكتوراه) في الطب الباطني. بورد عراقي (دكتوراه). . تخصص دقيق في أمراض وقسطرة القلب والشرايين. . Aqeel. Shams. M.B.Ch.B. /MSc. Clinical pharmacology. . Hypertension . is defined as a sustained systolic blood pressure of 140 mm Hg or higher or a sustained diastolic blood pressure of 90 mm Hg or higher. . when resting systolic blood pressure exceeds . 130 or diastolic . blood pressure exceeds 80 mm . Hg.. Even stage 1 hypertension (<140/90. ) has been reported to increase the risk of end-organ damage. Reverend Dr David CM Taylor. http:/www.liv.ac.uk/~dcmt. http://pcwww.liv.ac.uk/~dcmt/cvs10.ppt. intrinsic (Starling’s Law). extrinsic (principally autonomic). The story so far.... Stroke volume. Heart rate.