PPT-Blood pressure and the renin-angiotensin

system Dr Nish Arulkumaran SpR and Clinical Research fellow Imperial College London GEP Renal Feb2012 Systolic and Diastolic pressure Heart cycle systole and diastole Systole ventricular contraction ejection . Blood pressure normally rises and falls throughout the day but it can cause health problems if it stays high for a long time High blood pressure can lead to heart disease and strokeleading causes of death in the United States Are you at risk One in Mike Clark, M.D.. MAP = CO x SVR. CO = HR x SV. SV = EDV – ESV . (EDV concerned with blood volume and ESV concerned more with inotropic effect). SVR = ∑R₁ + R₂ + 1/R₃ + 1/R₄ …... R = 8ŋL/∏r⁴. Three mechanisms control the GFR . Renal autoregulation (intrinsic system). Neural controls. Hormonal mechanism (the renin-angiotensin system). Intrinsic Controls. Under normal conditions, renal autoregulation maintains a nearly constant glomerular filtration rate. Kelsey Davis, Courtney Getchell, Robert . Kolar. Introduction. We will be covering the topic of . prodrugs. , specifically a hypertension medication . Olmesartan. .. An introduction to . prodrugs. and what they are used for.. Blood pressure (BP) . is the pressure or tension exerted on the arterial walls as blood pulsates through them (principal vital sign). Systolic blood pressure (SBP) . – pressure exerted on the arteries during the contraction phase of the heartbeat. . Texas Children’s Hospital Advance Practice Providers Conference. Thursday, April 5, 2018. Common cardiac medications in the community: the heart of the matter . Disclosure. The speaker does not have any relevant financial or non-financial conflicts of interest to disclose.. To reach your hands and feet, blood has to leave your heart (Left Ventricle) under very . high pressure. . . Blood Pressure. The aorta . has the highest pressure. (100mm Hg). As the blood gets farther away and the blood vessels get smaller, the pressure decreases. . Blood Pressure Control Simplified Version Blood Pressure Control Widespread Control – Control all over the body A. Nervous System B. Hormones Local Control – Control of certain organs MAP = CO x SVR HYPERTENSION. BLOOD pressure that is above normal for sustained period . .. . Most common health problem In adults and the leading cause of cardiovascular . disorder.. Hypertension is the term used to describe high blood pressure. . High blood pressure is a condition that is also known as hypertension.. Having high blood pressure puts strain on your heart that can lead to your blood vessels becoming damaged, making them more at risk of heart disease.. BP. Congest-ion*. Haemo. -globin. K. +. GFR. BNP#. Echo. Diuretics. . . . . . . . ACEi/ARB. . . . I. ARNI. . . . I. I. β. -Blocker. R?. . R?. . I. MRA. . when resting systolic blood pressure exceeds . 130 or diastolic . blood pressure exceeds 80 mm . Hg.. Even stage 1 hypertension (<140/90. ) has been reported to increase the risk of end-organ damage. Converting. . Enzyme. . Inhibitors. . or . Angiotensin. . Receptor. . Blockers. . Use and. . Covid-. 19. . Infection . Among. . Patients with. . Hypertension. Jaejin. . An. ,. . Rong. . Wei,. Reverend Dr David CM Taylor. http:/www.liv.ac.uk/~dcmt. http://pcwww.liv.ac.uk/~dcmt/cvs10.ppt. intrinsic (Starling’s Law). extrinsic (principally autonomic). The story so far.... Stroke volume. Heart rate.