PPT-1 The Renin Angiotensin

System The Cardiovascular Continuum Myocardial Infarction Heart Failure EndStage Heart Disease Plaque Rupture Risk Factors Hypertension Hyperlipidemia Diabetes Atherosclerosis Endothelial Dysfunction. INTRODUCTION as anticoagulant. The genomic DNA was ex- ID polymorphism was determined by al-(Tiret et al. 1992). ID were 5'-CTGGAGAGCCACTCCCATCCTTTCT-3' (Forward) and5'-GACGTGGCCATCACATTCGTCAGAT-3' (R Mike Clark, M.D.. MAP = CO x SVR. CO = HR x SV. SV = EDV – ESV . (EDV concerned with blood volume and ESV concerned more with inotropic effect). SVR = ∑R₁ + R₂ + 1/R₃ + 1/R₄ …... R = 8ŋL/∏r⁴. hyperaldosteronism. (Conn’s syndrome):. An underdiagnosed disorder. i. n both humans and cats. . Michiel . Kerstens. . and. Hans Kooistra. Medulla. Zona Glomerulosa. Zona fasiculata. Zona Reticularis. Why is it important. Major intracellular ion (98%). Major determinant of resting membrane potential. (arrhythmia’s . etc. ). Long term = kidneys. Short term = intra-extra movement (serum K+ . doesn. Three mechanisms control the GFR . Renal autoregulation (intrinsic system). Neural controls. Hormonal mechanism (the renin-angiotensin system). Intrinsic Controls. Under normal conditions, renal autoregulation maintains a nearly constant glomerular filtration rate. Drugs Acting on the Renin-Angiotensin-Aldosterone System. Physiology of the renin-angiotensin-aldosterone system. Angiotensin-converting enzyme inhibitors. Angiotensin II receptor blockers. Aldosterone antagonists. Kelsey Davis, Courtney Getchell, Robert . Kolar. Introduction. We will be covering the topic of . prodrugs. , specifically a hypertension medication . Olmesartan. .. An introduction to . prodrugs. and what they are used for.. Blood Pressure. Dr . K. hwaja Amir. Assistant Professor. Objectives . By the end of this session, the student should be able to:. Outline the different mechanisms involved in regulation of ABP.. Discuss the role of reflexes especially baroreceptor reflex . Blockers. :. Impact on Adverse Outcomes in Hospitalized Patients . with Severe Acute Respiratory Distress Syndrome Coronavirus 2 (SARS-CoV-2). THE BRACE CORONA TRIAL. Renato D. Lopes, MD, PhD. on behalf of the BRACE CORONA Investigators. IN. TYPE I DIABETIC NEPHROPATHY. DR.NASIM MUSA. Type I –IDDM is characterized by. The abrupt onset of symptoms. Insulinopenia. Dependence on injected insulin for life. Proneness to . ketoacidosis. .. , MD. Professor of Internal Medicine . UT Southwestern Medical Center. Dallas, Texas. Robert Toto. , MD. Associate Dean. Clinical and Translational Research . Director, Center for Translational Medicine . when resting systolic blood pressure exceeds . 130 or diastolic . blood pressure exceeds 80 mm . Hg.. Even stage 1 hypertension (<140/90. ) has been reported to increase the risk of end-organ damage. system. Dr Nish . Arulkumaran. SpR. and Clinical Research fellow. Imperial College London. GEP – Renal, . Feb2012. Systolic and Diastolic pressure. Heart cycle = systole and diastole. Systole = ventricular contraction = ejection . Converting. . Enzyme. . Inhibitors. . or . Angiotensin. . Receptor. . Blockers. . Use and. . Covid-. 19. . Infection . Among. . Patients with. . Hypertension. Jaejin. . An. ,. . Rong. . Wei,.