PPT-Adverse drug Effects(ADR)

Introduction Adverse effect Any undesirable or unintended effect due to of drug administration It is broad term and includes all kinds of noxious effect such as trivial serious or even fatal. HIV. & . AIDS. . Hepatitis. Herpes Virus. Influenza. . Chapter 36. 1. Demographics. World-wide in 2006: 65 Million people living with HIV/AIDS. U.S.: . 1.1. Million cases to date:. 40,000 new cases each year. Adapted from NurseCE4less.com for Ambercare Corporation Education Department, 2014. OBJECTIVES. Describe the role of receptors related to medications. Discuss the four components of pharmacokinetics. the Fine Print: . Visualizing . Medication . Side-Effects in Complex Multi-drug Regimens. Jon D. Duke, . MD. NLM Medical . Informatics Fellow. Regenstrief. . Institute. Indiana University. The . QuARK. HTN. ). Chapter 23. Hypertension & Demographics. In the United States:. 74.5 Million adults Dx with HTN. 56,561 deaths in 2006, contributing factor in 300,000 additional deaths/year . Incidence is 1:3 adults, 77% unaware until diagnosed. HTN. ). Chapter 23. Hypertension & Demographics. In the United States:. 74.5 Million adults Dx with HTN. 56,561 deaths in 2006, contributing factor in 300,000 additional deaths/year . Incidence is 1:3 adults, 77% unaware until diagnosed. Objectives . Explain . Pharmacovigilance & various types of adverse drug reactions. . List . some common adverse effects & toxicities with examples. . Discuss . drug dependence & its public health importance. . Drug-Drug Interactions. Basic mechanisms of drug-drug interactions. Clinical significance of drug-drug interactions. Minimizing adverse drug-drug interactions. Drug-Drug Interactions. Interactions can occur whenever a patient takes more than one drug.. Visualizing . Medication . Side-Effects in Complex Multi-drug Regimens. Jon D. Duke, . MD. NLM Medical . Informatics Fellow. Regenstrief. . Institute. Indiana University. The . QuARK. Project. Quantitative Adverse . PATRICK DUFF, M.D.. POWER OF THE M.D.. POTENTIAL FOR HARM. Thalidomide. Valproic acid. Topiramate. MECHANISMS OF PLACENTAL TRANSFER. Simple diffusion. Facilitated diffusion. Active transport. Pinocytosis. Olha. . Vashkevych. Qing Huang. Fannyeu. . Liou. Yineeta Chitlall. Zetia. (. Ezetimibe. ). Pharmacologic category: . Atilipemic. . agent. Use: . Treatment of primary hypercholesterolemia . MOA: . Amebiasis. (also called amebic dysentery) is an infection of the intestinal tract caused by . Entamoeba. . histolytica. .. Therapeutic agents for . amebiasis. are classified as luminal, systemic, or mixed . (Res . eadem. . vulnus. . opemque. . feret. ). OVID, . Tristia. Appropriate Drug Prescribing in Older Adults. Objectives. Understand age-related changes in pharmacokinetics and . pharmacodynamics. Emergency psychiatry. Spectrum of emergency ADR in . psychotropics. Extrapyramidal adverse effects – dystonia, akathisia. NMS. Cardiac side effects. Haematological adverse effects. Cutaneous adverse effects. . Any noxious change which is . Suspected to be due to a drug. At. doses normally . used in man. May requires treatment or decrease in dose or . Caution in the future use of the same drug. ADVERSE DRUG EVENT (ADE.