PPT-Breast & Ovarian Cancer:

BRCA1 and BRCA2 Jennifer Hardee Normal function of the genes BRCA1 amp BRCA2 are in the same DNA repair pathway Despite names do not share any protein structure Both are tumor suppressors . †Source: U.S. Cancer Statistics Working Group. United States Cancer Statistics: 1999–2011 Incidence and Mortality Web-based Report. Atlanta (GA): Department of Health and Human Services, Centers for Disease Control and Prevention, and National Cancer Institute; 2014. Available at: http://www.cdc.gov/uscs. (full site) . Ovarian Cancer. Epithelial Tumor, . postmenopausal women. Germ cell,. younger women. Sex cord-stromal origin,. any age. Approximately 90% of ovarian cancer is epithelial . significant . therapeutic challenges . Talking point:. Genetics of ovarian cancer. 49F. Underwent risk-reduction surgery. Total hysterectomy and bilateral . salpingo. -oophorectomy. Significant family history . Sister passed away in her 40s due to breast cancer. Susan M. Domchek, MD. Basser Professor of Oncology. University of Pennsylvania . Sex. Age. Family . history. Depends on specific of family history. Depends on whether there is a k. nown . genetic . susceptibility. {Template Slide Set}. 1. Overview. What are Hereditary Breast and Ovarian Cancer syndrome (HBOC) and Lynch . s. yndrome (LS)?. How common are LS and HBOC? . How do LS and HBOC affect individuals and families?. Diagnostic work-up. Treatment. The most commonly occurring gynecologic cancer is:. Cervical. Endometrial. Ovarian. Vulvar. The gynecologic cancer with the highest death rate is:. Cervical. Endometrial. Improvement in 5 Year Survival:. Race. 1975. 1989. 2014. All. 36%. 38%. 47%. White. 35%. 38%. 48%. African American. 42%. 34%. 39%. Noone. AM, . Howlader. N, . Krapcho. M, et al. (eds). SEER Cancer Statistics Review, 1975-2015, National Cancer Institute, Bethesda, MD, www.seer.cancer.gov/csr/1975_2015/, based on November 2017 SEER data submission, posted to the SEER website April 2018.. Lisa McCluskey, MD. Gynecologic Oncologist. June 16, 2015. Compass Oncology . in partnership with . Ovarian . Cancer Alliance of Oregon & SW . Washington. What. is Ovarian Cancer. ?. The most common type of Ovarian Cancer that starts from . BRCA1 and BRCA2. Jennifer . Hardee. Normal function of the genes. BRCA1 & BRCA2 are in the same DNA repair pathway. Despite names, do not share any protein structure. Both are . tumor suppressors . Dr Katie Snape. Joint Lead Consultant for Cancer Genetics,. South West Thames Regional Genetics Service. St George’s University Hospitals NHS Foundation Trust. Approval ID: GB-17285. Date of Preparation: June 2019. 2/22/2007 p lus/ rint/enc Page 2of 3 2/22/2007 p lus/ rint/enc The information provided should not be used during any medical emergency or for the diagnosis or treatment of any medical condilicensed p 1 The Facts Ovarian cancer is the fourth most common cancer in women. Each year about 400 women are diagnosed with ovarian cancer in Ireland. The symptoms can be very vague, particularly when the d March 2019. Preview/Introduction. The Risk of Breast Cancer to Women. Does Mammography Save Lives?. When to Start and How Often Should Women Screen?. Risks Versus Benefits of Mammography. Breast Cancer: The Impact on Women. Background of lower back pain for 3/12 . No past medical Hx.. Social Hx: . Married 2 small children, works in hospital admin. Regular Menstrual periods. Family Hx: . Aunt: Breast Ca 55. Aims. O/E:. Palpable LN under the right axilla.