Smear + / - Culture + ve

 Smear + / - Culture + ve  Smear + / - Culture + ve - Start

2020-04-09 5K 5 0 0

Description

Gene . xpert. + . ve. 75 (64. %. ). (Live bacilli). (37 . Pulm. & 48 EPTB). Smear &. . Culture -. . ve. Gene . xpert. +. ve. 37 (32. %. ). (Dead bacilli). Smear &. . Culture + . ve. ID: 776521 Download Presentation

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Smear + / - Culture + ve




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Slide1

Smear + / -Culture +veGene xpert + ve75 (64%)(Live bacilli)(37 Pulm & 48 EPTB)Smear & Culture - veGene xpert +ve37 (32%)(Dead bacilli)Smear & Culture + veGene xpert -ve5 (4%)(Atypical Mycobacteria)

GeneXpert MTB/RIF

assay(n=117)

Slide2

GENE XPERT PERFORMANCE SPUTUM (n = 54)

Gold StandardGene xpert+veGene xpert - veCulture+ve15 (T+ve)0 (F-ve) Aty MbCulture -ve5 (F +ve) Dead34 (T –ve)

Slide3

GENE XPERT PERFORMANCE BRONCHIAL WASH (n = 52)

Gold StandardGene xpert+veGene xpert - veCulture+ve12 (T+ve)0 (F-ve) Aty MbCulture -ve3 (F +ve) Dead37 (T –ve)

Slide4

GENE XPERT PERFORMANCE Extra-Pulmonary Samples (n=153)

Specimen

No.

C+

ve

GeX

+

ve

Sensitivity (%)

Specificity(%)

PPV(%)

NPV (%)

CSF

78

4

100

89.19

33.3

100

Asp. Pus

26

18

100

52.63

43.75

100

Tissue

(bon)

23

11

100

78.95

50

100

Lymph node

26

15

100

63.64

33.3

100

Slide5

Extra-Pulmonary Samples –Culture & GeneXpert Negative (n=61)

SPECIMEN

NO.

Pleural

fluid

26

Ascitic fluid

22

Synovial fluid

6

Aspirated fluid

5

Pericardial

fluid

1

Peritoneal fluid

1

Slide6

GENE XPERT PERFORMANCE-Sensitivity

Analytical sensitivity

5

genome copies of purified DNA

131 CFU/ml

of

M.tb

Sensitivity =

100%

Negative Predictive value =

100%

Test accuracy =

100%

(detected all smear +

ve

/ Culture +

ve

)

Slide7

GENE XPERT PERFORMANCE -Specificity

SpecimenSpecificity (%)PPV (%)Sputum8775Bronchial wash9380CSF9033 Asp. Pus5344Tissue (bone)7950Lymph node6433

32%

Dead bacilli - Already treated cases

??


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