Metabolic Syndrome: Focused on AMPK as Molecular Target for Metabolic Syndrome - PowerPoint Presentation

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Metabolic Syndrome: Focused on AMPK as Molecular Target for Metabolic Syndrome

Bayu

Lestari

What will be Impaired in This Patient?

Obese

Insulin Resistance?

Dyslipidemia? (High TG, High LDL, Low LDL)

T2DM?

Metabolic Syndrome

High prevalence of metabolic syndrome: relation between glucose and lipid metabolismVarious clinical manifestations: T2DM, obese, dyslipidemia

New therapeutic approach required for efficient and high efficacy

AMPK was reported as potent molecular target for metabolic syndrome therapy

Background

Discuss about Metabolic SyndromeDiscuss about AMPK as molecular target for therapy

Aim

Cluster of syndrome: insulin resistance, high blood glucose, dyslipidemia, obeseImpairment both glucose metabolism and lipid metabolismCorrelation between glucose and lipid metabolism?

Metabolic Syndrome

Glucose Transport and How Insulin Resistance Occur

How Lipid Disorder Affect Insulin Resistance

Structure of AMPK

Activation Pathway of AMPK

Regulation of AMPK

How AMPK Activation Reduce Metabolic Syndrome

Enhanced translocation of GLUT4Enhanced expression of GLUT4 gene (Zheng et al, 2009)

Insulin independent pathway?

Role AMPK on GLUT4

mTOR Pathway

Insulin-mTOR pathway 

activation & phosphorylation

S6 kinase

I, down-regulation insulin receptor substrate-1 (IRS1) decrease insulin signalling

(Zheng et al, 2009)

Role AMPK in Insulin Sensitivity

AMPK activation  improve mitochondrial function via expression of

peroxisome

proliferator-activated receptor-γ

(PPAR-γ) coactivator-1α (PGC-1α)  reduce insulin resistance  reduce development of T2DM (Zheng

et al, 2009)Role AMPK in Mitochondrial Biogenesis

Role AMPK in Lipid Metabolism

Lipid Oxidation

Lipogenesis

Metabolic syndrome: cluster of syndromes (insulin resistance, dyslipidemia, obese)AMPK has beneficial role as molecular target for metabolic syndrome’s therapy

Conclusion

Thank You