PPT-Disorder of blood coagulation in pregnancy

Dr shatha Sami alyasrri Assistant professor Bleeding disorders during pregnancy and delivery A Inherited Vascular abnormalities Platelet disorders Coagulation disorders BAcquired Thrombocytopenia. Abnormalities of Blood Coagulation. Learning Objectives. Describe functions of blood vessels and platelets in controlling bleeding. Explain three phases of coagulation and the respective factors involved. By: . Jingtian. . Weng. , Cindy Nguyen, Cassandra Lee, Sarah Bento-De Sousa. Presentation Date: Sept. 13, 2016. PHM142 Fall . 2016. Instructor: Dr. Jeffrey Henderson. What is COX?. Two homodimer enzymes COX-1 and COX-2. Sulistyo. . Rini. , . MSc. Five Stages of . Hemostasis. Vessel spasm. Formation of the platelet plug. Blood coagulation or development of an insoluble fibrin . clot. Clot retraction . Clot dissolution . haemostasis. Vascular bleeding disorders:. .The underlying . abnormalities are. either in the . vessels themselves. . perivascular. connective tissue. .. Each could be. Inherited. Acquired. . autosomal. :. are additives that inhibit clotting of blood and/or plasma. They act either by binding calcium ions or by inhibiting thrombin activity. . Platelets and coagulation factors are activated when blood vessels are punctured, and their activation continues in sample containers that do not contain anticoagulant, leads to clot formation which interfere with many analytical tests.. Christina L. Wichman, DO, FACLP. Medical Director, The Periscope Project. Director, Women’s Mental Health. Associate professor of Psychiatry & behavioral Medicine and Obstetrics & Gynecology. DONE BY. MSC ZAHRAA ABDUL GHANI M.A.. Hypertensive . Disorder of Pregnancy . I. Gestational hypertension . Is defined as a persistent systolic blood pressure level of 140 mm Hg or greater or a diastolic blood pressure level of 90 mm Hg or greater . Bruce Furie and Barbara C. Furie Center for Hemostasis and Thrombosis Research Division of Hematology/Oncology Departments of Medicine and Biochemistry New England Medical Center and Tufts University M. AND J. E. WYNANDS, M.D., C.IVI.~ THE V~Y F_~aLY STUVmS of this subject, many controversies existed regard- ing the various factors and mechanisms involved in the dotting process. One simply has to gestation. Ddimer and VIII significantly increased from prepregnancy levels by 59 days gestation. Estradiol significantly increased byDay gestation with a nonsignificant increase of 67% by Day 24 ges According to Howell Theory of blood coagulation , the change of fibrinogen into fibrin is caused by thrombin which in fluid exists as prothrombin. The conversion of prothrombin to thrombin depends on the action of thromboplasin and calcium. . Professor . Dr.Noori. Mohammed . Luaibi. HEMOSTASIS EVENTS . The . term hemostasis means prevention of blood loss. Whenever a vessel is severed or ruptured, hemostasis is achieved by several mechanisms: (. The stoppage of . bleeding. or . hemorrhage. The normal . haemostatic. response; . to vascular damage depends on a closely linked interaction between the . blood vessel wall. , . circulating platelets. Nervana. . Bayoumy. . Associate . Professor. Department of Physiology. . Objectives. At the end of this lecture . you . should be able to:. Recognize the different clotting factors. U. nderstand the role of calcium ions during clotting cascades..