PPT-Clotting mechanism &coagulation profile

Platelets Thrombocytes Are small irregularly shapedoval non neocleated cells 23 µm in diameter derived from fragmentation of precursor megakaryocytes bone marrow The average lifespan of a platelet is between 8 and 12 days . Tube Method . Mr. Mohammed A. Jaber. Coagulation Time ( Clotting Time) CT.. Clotting time was used as a screening test to measure all stages in the intrinsic coagulation system and to monitor heparin therapy .. Dr. . Mahvash. Khan. MBBS, MPhil. Occurs inside the blood vessels, it is also called fibrinolysis. Occurs due to a substance known as plasmin (. fibrinolysin. ). Plasmin is formed from plasminogen (. Guy Young, MD. Children’s Hospital Los Angeles. University of Southern California Keck School of Medicine. Abbreviations. Abbreviations will be explained the first time the term appears on a slide. Cardiovascular System: Blood Clinical Anatomy Tony Serino, Ph.D . Blood: Topic Objectives Be able to describe the physical properties of the blood including its components. Be able to explain how blood cells develop and what key ingredients are necessary in RBC development.  . Platelets . are small colorless. ,. Non . nucleated and moderately refractive bodies which are considered to be the fragments of cytoplasm. .. . Diameter. : 2.5 μ (2 to 4 μ). Volume: 7.5 cu μ (7 to 8 cu μ. Sulistyo. . Rini. , . MSc. Five Stages of . Hemostasis. Vessel spasm. Formation of the platelet plug. Blood coagulation or development of an insoluble fibrin . clot. Clot retraction . Clot dissolution . Introduction. Blood—made up of plasma and formed elements. Blood—complex transport medium that performs vital pickup and delivery services for the body. Blood—keystone of body’s heat-regulating mechanism. According to Howell Theory of blood coagulation , the change of fibrinogen into fibrin is caused by thrombin which in fluid exists as prothrombin. The conversion of prothrombin to thrombin depends on the action of thromboplasin and calcium. . Professor . Dr.Noori. Mohammed . Luaibi. HEMOSTASIS EVENTS . The . term hemostasis means prevention of blood loss. Whenever a vessel is severed or ruptured, hemostasis is achieved by several mechanisms: (. Part of ECF. Has two portions. Cellular components. Erythrocytes (Red blood corpuscles - RBC). Leukocytes (White blood corpuscles – WBC). Thrombocytes. (Platelets). Extracellular components. Water. . Classify drugs acting as anticoagulants. . Elaborate on their mechanism of action, correlating that with methods of monitoring. . Contrast the limitations & benefits of injectable anticoagulants in clinical settings. antiphospholipid. syndrome. A short . tributededicated. to the memory of Dr. Virgil Woods Jr.: brilliant and generous scientist, dedicated mentor, and truly compassionate physician. by. Nunzio. Bottini, MD, PhD. Dr. Mohammad Al-. Katari. Consultant Adult Hematology & Internal Medicine. King Khalid University Hospital – King Saud University. Outlines . Bleeding Disorders. Overview of Hemostasis.. Approach to the bleeding Pt.. Nervana. . Bayoumy. . Associate . Professor. Department of Physiology. . Objectives. At the end of this lecture . you . should be able to:. Recognize the different clotting factors. U. nderstand the role of calcium ions during clotting cascades..