PPT-PCBs – Mechanisms of Toxicity

Gabriele Ludewig PhD University of Iowa PCBs in Schools Risk eLearning Webinar April 28 2014 Outline Human diseases and PCBs Receptordriven mechanisms AhR RYR ER Metabolic activation. One Program’s BMP Update for Used Oil. -Rick Gilbert, Kitsap County Solid Waste. Kitsap County, Washington. Current Used Oil Program. Locations. Volume. “If It . Ain’t. Broke…”. Is it Broke?. . Overview of the Regulations. (What are the rules?). The Current PCB Regulations 40 CFR Part 761. Section . 6(e) of the Toxic Substances Control . Act of . 1976 . (. TSCA. ). Generally bans manufacture. Dioxins and PCBs. What are Dioxins and PCBs?. Dioxins are . colourless. , . odourless. organic compounds . containing carbon, hydrogen, oxygen and chlorine. . There are . many different dioxins. , of which 17 are known to be toxic to humans. . Presented by Rick Eichstaedt. March 26, 2013. Polychlorinated Biphenyls (PCBs). 209 . congeners. Congeners differ . in. Abundance . Physical properties . Biological effects . Aroclors. are mixtures of congeners . Presented by Rick Eichstaedt. March 26, 2013. Polychlorinated Biphenyls (PCBs). 209 . congeners. Congeners differ . in. Abundance . Physical properties . Biological effects . Aroclors. are mixtures of congeners . . Taken by . Hyogo Prefecture. （. Takasago West Port. ）. Hyogo Prefectural Government . Agricultural and Environmental Affairs Dept. Environmental Management Bureau, . Water and Air Quality Control Division. Director of Proposal Development & . Principal in Charge of PCB Remediation Activities. March 30, 2011. Managing PCB Contaminated . Building Materials . PCBs In Building Materials. Where they are found ?. ��(more)For Immediate Release: March 201 ��Organic Chemical Found of Walls of Kauai Water TankPage 2On March 14, 2013, DOH learned that scrapings from the inner wall of the Serumpolychlorinatedbiphenylsandleukocytetelomerelengthinahighly-exposedpopulationTheAnnistonCommunityHealthSurveyCatherineLCallahanMarianPavukLindaSBirnbaumXuefengRenCorrespondingauthoratNationalCanc INFORMATION & SAFETY. WHAT IS . E-WASTE?. Waste from discarded electrical and electronic equipment without intent of re-use is called . E-Waste. .. EXPOSURE IN RECYCLING . OF . E-WASTE. Recycling of electronics can be a source of many toxic chemicals including: Metals, Organic chemical compounds, Polychlorinated biphenyls (PCBs).. By Sara DeLeon, Rayko Halitschke, Ralph S. Hames, Andre Kessler, Timothy J. DeVoogd, and Andre A. Dhondt. PLoS. ONE 8(9):e73471. doi:10.1371/journal.pone.0073471, 2013 . Presented by . Erum. . Hadi. ToxCast data to predict acute toxicity. Dan Wilson, PhD, DABT. Science Leader – Cheminformatics. The Dow Chemical . Company. ddwilson@dow.com. (989)636-0712. EPA’s Computational Toxicology Communities of Practice. . Moderator: Mark Maddaloni . DrPH. , DABT. Introduction. `. 2. Polychlorinated Biphenyls (PCBs). Common. Aroclors. Chlorine . Weight %. Number . of . Congeners. Aroclor 1221. 21%. 60+. Aroclor 1232. April 28, 2014. 1. Evaluating Health Risks from Inhaled PCBs: Research Needs to Address Uncertainty . Geniece M. Lehmann, Ph.D. (U.S. EPA/ORD). History of U.S. interest in health risks of PCB inhalation.