Danger comes from the active catalysts Absorb hydrogen gas Can spark spontaneously and may ignite on exposure to air Readily causes ignition of flammable solvents in the presence of air Use in presence of H ID: 790174
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Pd/C and Hydrogenation
Slide2Pd/ C Hydrogenations
Danger comes from the active catalysts
Absorb hydrogen gas
Can spark spontaneously and may ignite on exposure to airReadily causes ignition of flammable solvents in the presence of air.Use in presence of H2 gas, sometimes at high pressure and temp.In the event of fire, contain it with waterTypes of CatalystsDegussa – safestWet – safer. Higher % of waterDry
Perry, David. Hazards in Hydrogenation.http://chemicalspace.wordpress.com/2010/07/27/hazards-in-hydrogenation/
Do not operate near flammable materials
Slide3Correctly done, these reactions can be routinely run safely
Weigh and add catalyst first
Flush vessel with nitrogen.
Handle Pd/C under inert atmosphere.Add solvent. (Degas solvent with large scale > 100 mL) Use ethanol, not methanol (very flammable, invisible flame)Flush reaction vessel with N2 , run reaction, repeat flush with N2Remove Pd/C through filtration (celite on glass frit), and cover with wet sand. Filter cake should never be allowed to dry, and the moist material should be added to a large quantity of water and disposed of properly.Dispose of waste in dedicated container that contains water. Know how to use the equipmentDon’t over-pressurize
Don’t use damaged equipment or glassware. Pd/ C Hydrogenations
Prudent Practices in the Laboratory: Handling and Disposal of Chemicals Laboratory Chemical Safety Summary: Palladium on Carbon
Slide4Pd/C
According
to Prudent Practices in the Laboratory,
palladium on carbon catalysts containing adsorbed hydrogen are pyrophoric, particularly when dry and may ignite on exposure to air
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