PPT-SANGUINATE TM Toxicology and Safety Determination

October 20 2014 Hemant Misra PhD hmisraprolongpharmacom SANGUINATE Therapeutic Need 2 Conditions in patients with hemoglobulinopathies are more complex and variable than in healthy humans due to the cascade of injury from hypoxia. Topics for Principles of Toxicology: Part B. Endocrine Toxicity. Carcinogenicity. Neurotoxicity. Persistence and Bioaccumulation. The topics for “Part C” (what we could not cover). Summary. The systemic problem. Lecture 1: Principles of Toxicology. Principles of Toxicity. Defining toxicology. History of toxicology. Dose response. Evaluating safety. Toxicology. Toxicology is the study of adverse effects of . chemicals . Director In Vivo Facility Michigan State University, . Chief Development Officer Integrated Nonclinical Development Solutions (INDS) Inc.. Safety Pharmacology Endpoints: Integration into Toxicology Studies. Toxicology. Poison is any substance that can harm or . kill.. Toxicology is the study of poisons.. Forensic Toxicology . is the study of postmortem . signs of the poisoning.. Toxicology. The idea of poison came from the Greek word, “. Tracie Phillips, Ph.D. & Roberta Grant, Ph.D.. Toxicology Division. Texas Commission on Environmental Quality. Environmental Trade Fair 2015. Objectives. New Toxicology Database:. Database Introduction. 2. Toxicology. Toxicology. —. the study of the adverse effects of chemicals or physical agents on living organisms. Types:. Environmental. —. air, water, soil. Consumer. —. foods, cosmetics, drugs. The Study of Poisons. Beginning the Journey into. Toxicology. Murder Magic and Medicine. The Goals of this course. Introduce the Principles of Toxicology. Part A. History of Toxicology. Dose-response. Overview. Overview. . of. . the. . Food. . and. . Drug. . Administration. . (FDA).  . • . . Regulatory. . Agencies. . Outside. . of. . the. . United. . States.  . • . . Overview. Washington State Toxicology Lab. Washington State Patrol. Brian Capron. Laboratory Staffing Updates. New Laboratory Manger: Dr. Brianna Peterson . Two toxicologists still on maternity leave. Lisa Noble (return November). Dr.. . Nirbhay. Kumar. Asstt. . Professor & Head. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. Branches of . Toxicology. Compilation of EU Dioxin Exposureand Health DataTask 8 - Human toxicologyReport produced forEuropean Commission EnvironmentUK Department of the Environment, Transport and theRegions (DETR)October 1999 Carcinogenicity. and . Teratogenicity. B.Pharm. . Sixth Sem.. BP602T. GENOTOXICITY. It is a word in genetics defined as a destructive effect on a cell's genetic material (DNA, RNA) affecting its integrity.. Tim MacLachlan, PhD, DABT. Chair. , . BioSafe . Leadership Committee. Executive Director, Biologics . Safety Assessment Preclinical . Safety, Novartis. The . opinions expressed in this presentation reflect those of the presenter(s) (or speaker(s)) only and do not . Introduction. Toxicology is the study of adverse effects of xenobiotics in humans.. Xenobiotics—chemicals and drugs not normally found or produced in the body. .. Three major disciplines within toxicology.