PPT-Why and how to test for germline

BRCA mutations in Pancreatic Cancer ESDO Learning Bytes December 2021 Alica Katrin Beutel Department of Internal Medicine I University Hospital Ulm Germany BRCA BReast CAncer Susceptibility Genes. in familial breast cancer . . can . lie deep in . family . tree. San Ming . Wang. University of Nebraska Medical Center. Genetically defined breast cancer. Sporadic . B. reast . C. ancer . caused by . in familial breast cancer . . can . lie deep in . family . tree. San Ming . Wang. University of Nebraska Medical Center. Genetically defined breast cancer. Sporadic . B. reast . C. ancer . caused by . Robin Shattock. . Experimental . Medicine . Trials - Why. Scientific:. Animal models are not fully predictive of human responses . There are germ line differences between humans and experimental animals. Specification . of Primordial Germ Cells. (PGCs) . (~ Week 2). Exploring Derivation of Germ Cells from Pluripotent Stem Cells. Azim Surani. Director of . Germline. and . Epigenomics. Research. University of Cambridge. -Mutated Ovarian Cancer. This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States and data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.. Karchin Lab. Department of Biomedical Engineering. Institute of Computational Medicine. Johns Hopkins University. SSID: . ASHGWORKSHOP. WiFi. Password. : . ASHGWORKSHOP. Select the SSID: . ASHGWORKSHOP. Opinion. 55 year-old woman with . recurrent . ovarian cancer. Underwent an optimal . cytoreductive. surgery and placement of an intraperitoneal catheter. Disease progressed through multiple lines of chemotherapy. Kyle Orwig. Magee-. Womens. Research Institute. University of Pittsburgh School of Medicine. International Summit on Human Gene Editing:. A Global Discussion. December 1-3, 2015. Stem Cell. Renewal. 12 – 13 November 2019, Singapore. www.gfbr.global.  .  .  .  . The GFBR. Funded by Bill & Melinda Gates Foundation, UK Medical Research Council, US National Institutes of Health, and . Wellcome. We performed a genome-wide analysis of gene expressionto identify germline- and sex-regulated genes.Using mutants that cause defects in germ cell proliferationor gametogenesis, we identiÞed sets of g Status is ubiquitous in modern life, yet our understanding of its role as a driver of inequality is limited.  In Status, sociologist and social psychologist Cecilia Ridgeway examines how this ancient and universal form of inequality influences today’s ostensibly meritocratic institutions and why it matters. Ridgeway illuminates the complex ways in which status affects human interactions as we work together towards common goals, such as in classroom discussions, family decisions, or workplace deliberations. Ridgeway’s research on status has important implications for our understanding of social inequality. Distinct from power or wealth, status is prized because it provides affirmation from others and affords access to valuable resources. Ridgeway demonstrates how the conferral of status inevitably contributes to differing life outcomes for individuals, with impacts on pay, wealth creation, and health and wellbeing. Status beliefs are widely held views about who is better in society than others in terms of esteem, wealth, or competence. These beliefs confer advantages which can exacerbate social inequality. Ridgeway notes that status advantages based on race, gender, and class—such as the belief that white men are more competent than others—are the most likely to increase inequality by facilitating greater social and economic opportunities. Ridgeway argues that status beliefs greatly enhance higher status groups’ ability to maintain their advantages in resources and access to positions of power and make lower status groups less likely to challenge the status quo. Many lower status people will accept their lower status when given a baseline level of dignity and respect—being seen, for example, as poor but hardworking. She also shows that people remain willfully blind to status beliefs and their effects because recognizing them can lead to emotional discomfort. Acknowledging the insidious role of status in our lives would require many higher-status individuals to accept that they may not have succeeded based on their own merit many lower-status individuals would have to acknowledge that they may have been discriminated against. Ridgeway suggests that inequality need not be an inevitable consequence of our status beliefs. She shows how status beliefs can be subverted—as when we reject the idea that all racial and gender traits are fixed at birth, thus refuting the idea that women and people of color are less competent than their male and white counterparts. This important new book demonstrates the pervasive influence of  status on social inequality and suggests ways to ensure that it has a less detrimental impact on our lives. Laura Yarram-Smith . Solid Tumour Lead SWGLH. July 2023. https://www.nbt.nhs.uk/south-west-genomic-laboratory-hub. Part of a Genomic Medicine Service. Bristol Clinical Genetics . Peninsula Clinical Genetics. FRCPath. MFPH MSc (Epidemiology). Professor in Translational Cancer Genetics. , Institute of Cancer Research. NHS Consultant in Clinical Genetics . (Honorary), Royal Marsden NHS Foundation Trust. Consultant in Public Health Medicine . testing . pathways. Format. Round table discussion . 5 working groups . –. Breast, Colorectal, Ovarian, Other, TP53. Three documents on table. Individual variant testing scoring form (all to complete).