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300337 - PowerPoint Presentation

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300337 - PPT Presentation

Borodovsky a short intro Position open Scientist Pathway Informatics June 2009 THE POSITION The successful candidate will join the Computational Science amp Bioinformatics team ID: 300337

biology bioinformatics analysis phd bioinformatics biology phd analysis systems gene university computational research jobs networks expression disease pathways data

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Presentation Transcript

Slide1

---- Mark

Borodovsky

a short intro

Position open:

Scientist - Pathway Informatics (June 2009)

THE POSITION

The successful candidate will join the Computational Science & Bioinformatics team

and will play a major role in the processing and

analysis of large scale data sets

from

various post genomic technologies

and their applications in biomarker discovery.

He/she will also have responsibility for

establishing and maintaining analysis

pipelines geared toward the identification of disease signature genes and pathways

from experimental system response profiles.

He/she will have the opportunity to apply and when necessary

develop methods

for systems wide analysis of gene expression patterns, their transcription factor

and epigenetic control, and the role of small RNAs in regulating gene/protein products

.

Specifically,

you will:

Establish innovative computational analysis for identification of deregulated pathways

in various disease states

Provide analysis of large scale array based data (genomics,

transcriptomics

,

proteomics

) to support the Computational Disease Biology team

THE PERSON

You have

PhD in bioinformatics

or related field

You have academic or industrial experience in bioinformatics with focus on

integrated analysis of biological systems

(gene/protein expression data,

array CGH,

ChiP

-chip)

Good programming skills in Perl, C/C++,or Java

,

you have also solid expertise in R/

Bioconductor

, or

Matlab

You have previous

experience in Gene Regulatory Network reconstruction

and pathway analysis Slide2

This International Research Training Group (IRTG) is formed by groups from

Humboldt University Berlin, Free University Berlin, Boston University,

Kyoto University and the University of Tokyo.

It focuses on the education of doctoral students

in the

emerging field of genomics and systems biology of

biomolecular

networks.

The processes to be studied carry out fundamental processes within living cells,

such as metabolic

interconversions

, cell division, cell differentiation and apoptosis.

The basic research performed in this program is highly relevant for future

medical applications, in particular with respect to cancer and other diseases

resulting from a dysfunction of signaling pathways and gene-regulatory networks.

The IRTG provides the doctoral students with a wide range of interdisciplinary

and topical research projects in four areas:

(A) Dynamics and topology of metabolic networks,

(B) Regulation of gene expression,

(C) Intra- and intercellular signal transduction, and

(D) Structure and function of protein families.Slide3

Candidates/jobs ratio

May & June 2009,

source: naturejobs.org

BINF

252

jobs

SystemsBio

21 jobsSlide4

Question #

1

Bioinformatics community has grown up earlier than the Systems Biology one;

PhD

in Bioinformatics programs has already been in place at many universities.

Now

Systems Biology may become a

new name

for a PhD major.

Should a System Biology PhD program be separate from a Bioinformatics PhD

program

?

or

Should

a PhD in Bioinformatics extend its name to PhD in Bioinformatics and

Systems

Biology (Comp Bio)?

Question #2

Will addition of

wet lab

courses to Computational Biology graduate training

lead

to loosing the Comp Bio identity?

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