PPT-Breast Cancer Proteomics and the use of TCGA Mutational Dat

Broad Institute updateissues Karl Clauser CPTAC Data Jamboree October 16 2012 Bethesda MD 1 Clustering of mRNA Expression and Breast Cancer Subtypes 2 TCGA Nature 2012 A CPTAC goal is. G. -matrix. Adam G. Jones (Texas A&M Univ.). Stevan. J. Arnold (Oregon State Univ.). Reinhard. . B. ürger. (Univ. Vienna). β. is a vector of directional selection gradients.. z. is a vector of trait means.. Rachna Raman MD MS. Hematology and Medical Oncology. Bon Secours Cancer Institute at St. Mary’s Hospital. Objectives. Risk factors . Screening guidelines and controversies. Screening and management of patients at high risk for breast cancer. Inspection. Size. S. ymmetry (some variation is normal) . Shape. Contour (flattening, masses, and dimpling). S. kin (color, edema, rashes, thickening, and venous pattern). S. cars (previous surgery, injuries). By: Jeanette . Monroy. California State University, Long . Beach. May 2012. Introduction. & Goals. Currently. , it is estimated that in California 1 in 20 Latinas will develop breast cancer during their lifetime (California Department of Health Services, 2010). . Matthew Beatty, Brynn Cullander, Melissa Frank, Justin Ludwig, Mosharaf Mahmud Syed, Andrew Pierce, and Ashton Sigler. History. Discovered in the 1984 by Roel Nusse and Harold Varmus as the int1 gene.. {Template Slide Set}. 1. Overview. What are Hereditary Breast and Ovarian Cancer syndrome (HBOC) and Lynch . s. yndrome (LS)?. How common are LS and HBOC? . How do LS and HBOC affect individuals and families?. BRCA2 is a tumor suppressor gene responsible for DNA repair . BRCA2 was discovered in breast cancer tumors of patients without BRCA1 mutations. Mice knockouts discovered that BRCA2 is directly involved in double strand break repair. Steven J. Katz MD MPH. Professor of Medicine and Health Management and Policy. University of Michigan . Allison Kurian MD M Sc.. Professor of Medicine and Medical Genetics . Stanford University . Guidelines 2019. Kate R. Rosenbloom, Hiram Clawson, Mark Diekhans, Luvina Guruvadoo, Rachel A. Harte. 1,2. , Donna Karolchik, Brian T. Lee, Brian J. Raney, Ann S. Zweig, . David Haussler. 1,3. , Robert M. Kuhn, W. James Kent. cBioPortal. . Nitish . Mishra. TCGA history. TCGA is a project, begun in 2005, to catalogue genetic mutations responsible for cancer, using genome sequencing.. TCGA is supervised by the Center for Cancer Genomics and the National Human Genome Research Institute. A three-year pilot project, begun in 2006, focused on characterization of . Most of these lesions are benign. Breast cancer is 2. nd. most common cause of cancer deaths in women, following. carcinoma of the lung. . The clinical significance of the . benign. conditions:. 1- possible clinical confusion with malignancy. Ryan Fellers, Proteomics Center of Excellence. OSG All Hands Meeting, 3/24/2015. Agenda. Introduction to Proteomics. What is it?. Top Down Proteomics specifics. Tools . and Support. Legacy of Tool Development.  breast tissue, . most . commonly from the inner lining . of.  milk ducts or the lobules that supply the . ducts . with . milk.. Breast cancer may be invasive or noninvasive. . Invasive. Imaging . Information Correlated with TCGA Samples. Fred Prior. 1. , John Freymann. 2. , . Bruce Vendt. 1. ,. . Ken Clark. 1. , . Justin Kirby. 2. , Lawrence Tarbox. 1. , Paul Koppel. 1. , . Stephen Moore.