PPT-The Cancer Genome Atlas (TCGA) and

cBioPortal Nitish Mishra TCGA history TCGA is a project begun in 2005 to catalogue genetic mutations responsible for cancer using genome sequencing TCGA is supervised by the Center for Cancer Genomics and the National Human Genome Research Institute A threeyear pilot project begun in 2006 focused on characterization of . Elaine R. Mardis, Ph.D.. Professor of Genetics. Co-director, The Genome Institute. NCI Workshop: NGS in Clinical Decision Making. Why is cancer WGS analysis “easy”?. The comparison of a patient’s tumor to their normal genome . scriptomedataproducedbyTheCancerGenomeAtlas (TCGA)toidentifylarge-scaledifferencesinRNAspli- cingbetweentumorandnormalcontrolsamplesacross 16distinctcancertypes.Whileweobservednoobvious biasesincasset Broad . Institute update/issues. . Karl Clauser. CPTAC Data Jamboree. October . 16, . 2012. Bethesda, . MD. 1. Clustering of mRNA Expression and Breast Cancer Subtypes. 2. TCGA Nature 2012. A CPTAC goal is. Cancer Informatics (omics). David Boone. Outline. What is cancer and how is it different from other diseases?. Major players in tumor initiation (Understand one before many) . Oncogenes. Tumor suppressors. Cancer Informatics (omics). David Boone. Outline. What is cancer and how is it different from other diseases?. Major players in tumor initiation (Understand one before many) . Oncogenes. Tumor suppressors. Next Generation Sequencing. Hanlee Ji, M.D. . ã . Stanford University. Overview. Principles of next generation . DNA sequencing. Analysis of genetic variation and research applications. The Cancer genome atlas (TCGA) and the search for a CUP genetic/epigenetic signature Manel Esteller , MD, PhD. Director, Josep Carreras Leukaemia Research Institute (IJC) Director, Cancer Epigenetics and Biology Program (PEBC) Tim Graubert, MD. Division of Oncology, Stem Cell Biology Section. Washington University School of Medicine. Siteman Cancer Center. Genome Center at Washington University. Genome Center Leadership. Rick Wilson. Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers. Contributors: . Fazlur Rahman Talukdar. , Sheila C. Soares Lima, Rita . Khoueiry. , . Ruhina. Shirin . Laskar. , . 15 . Gene . E. xpression . S. ignature . to . Detect . a . Subgroup . D. riven . by MAPK . Signalling. Abstract No: 1777 . 1. Centre for Cancer Research and Cell Biology, Queens University Belfast, Northern Ireland, . for suspected cancer Information for patients and family members Genomic Medicine Service NHS What is your genome? Your genome is the information needed to build the human body and keep it health Specificity and Universal Cancer Detection using Plasma. James G. Herman, M.D.. Jeff Wang, Ph.D.. The UPMC Hillman Cancer Center. The University of Pittsburgh. The Johns Hopkins University. Highly Prevalent Tumor Specific Methylation Defined for Lung CA. Imaging . Information Correlated with TCGA Samples. Fred Prior. 1. , John Freymann. 2. , . Bruce Vendt. 1. ,. . Ken Clark. 1. , . Justin Kirby. 2. , Lawrence Tarbox. 1. , Paul Koppel. 1. , . Stephen Moore. Justin Kirby – justin.kirby@nih.gov . Frederick National Laboratory for Cancer Research. Leidos Biomedical Research, Inc.. Informatics in Cancer Imaging (ICI) Team. Support to: Cancer Imaging Program/DCTD/NCI.