Scott Walmsley, PhD. Research Instructor, Department Pharmaceutical Sciences. Skaggs School of Pharmacy. Outline . What is and why perform Multiple . S. equence . A. lignment (MSA)?. Pre-requisite knowledge.
Tandy Warnow. The Department of Computer Science. The University of Texas at Austin. The “Tree of Life”. Avian Phylogenomics Project. G Zhang, . BGI. . Approx. 50 species, whole genomes. 8000+ genes, UCEs.
CS/. BioE. 598. Tandy Warnow. Alignment Error/Accuracy. SP-FN: percentage of homologies in the true alignment that are *not* recovered. SP-FP: percentage of homologies in the estimated alignment that are false.
Jia. -Ming Chang, Paolo Di . Tommaso. , and Cedric . Notredame. TCS. : A new multiple sequence alignment reliability measure to estimate alignment accuracy and improve phylogenetic tree . reconstruction, .
Tandy . Warnow. Studies we will discuss. Katoh. and . Standley. , MBE 2013 (about MAFFT). Nelesen. et al., PSB 2008 (Impact of guide tree). Liu and Warnow, . PLoS. ONE 2012 (about treelength criteria).
and Sequence Profiles. Multiple sequence alignment. Generalize our pairwise alignment of sequences to include . more than two. homologous proteins.. Looking at more than two sequences gives us . much more information.
Tandy . Warnow. Joint with Mike . Nute. and Ehsan Saleh. https://. www.biorxiv.org. /content/early/2018/04/20/304659. Performance Study on bioRxiv . Goal: Evaluate . Bali-Phy. (Redelings and Suchard) on both biological and simulated datasets, in comparison to leading alignment methods on small protein sequence datasets .
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Multiple Sequence Alignment Methods
Presentation on theme: "Multiple Sequence Alignment Methods"— Presentation transcript: