TCS: A new multiple sequence alignment reliability measure - Description
Jia Ming Chang Paolo Di Tommaso and Cedric Notredame TCS A new multiple sequence alignment reliability measure to estimate alignment accuracy and improve phylogenetic tree reconstruction ID: 244621 Download Presentation
Scott Walmsley, PhD. Research Instructor, Department Pharmaceutical Sciences. Skaggs School of Pharmacy. Outline . What is and why perform Multiple . S. equence . A. lignment (MSA)?. Pre-requisite knowledge.
and Sequence Profiles. Multiple sequence alignment. Generalize our pairwise alignment of sequences to include . more than two. homologous proteins.. Looking at more than two sequences gives us . much more information.
Tandy Warnow. The Department of Computer Science. The University of Texas at Austin. The “Tree of Life”. Avian Phylogenomics Project. G Zhang, . BGI. . Approx. 50 species, whole genomes. 8000+ genes, UCEs.
Places residues in columns . per . position specific similarity scores . reflects . relationships . of the . sequences. the scores are based on . indels. (gaps) and substitutions.. The alignment of residues implies that they have similar roles in the proteins or DNA sequences being aligned .
Jamie DeLeeuw, Ph.D.. 5/7/13. Reliability. Consistency of measurement. The measure itself is dependable.. ***A measure must be reliable to be valid!***. High reliability = greater consistency = lower randomness (error).
a case study on transmembrane protein. Jia-Ming Chang. 2013-July-09. Chang, J-M, P Di Tommaso, J-. Fß. Taly, C Notredame. 2012. Accurate multiple sequence alignment of transmembrane proteins with PSI-Coffee. BMC Bioinformatics 13..
Jia. -Ming Chang, Paolo Di . Tommaso. , and Cedric . Notredame. TCS. : A new multiple sequence alignment reliability measure to estimate alignment accuracy and improve phylogenetic tree . reconstruction, .
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TCS: A new multiple sequence alignment reliability measure
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