The Negative Checkpoint Receptor TIGIT Marks
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The Negative Checkpoint Receptor TIGIT Marks

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The Negative Checkpoint Receptor TIGIT Marks




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Presentation on theme: "The Negative Checkpoint Receptor TIGIT Marks"— Presentation transcript:

Slide1

The Negative Checkpoint Receptor TIGIT Marks

Exhausted T cells During SIV Infection and Correlates with SIV Disease Progression

Gabriela WebbVaccine and Gene Therapy InstituteOregon Health and Science UniversityJuly 21, 2015

Slide2

CD8+ T cell

TIGIT

CD155

PD1

PDL1

P

roliferation

Cytokine production

TCR

+

-

-

Rhesus TIGIT shares 88.1% sequence homology with human TIGIT

High antigenic load environment

 T cell exhaustion

Slide3

TIGIT expression is increased in SIV+ RMs and correlates with viral load

Slide4

TIGIT is also found on SIV-specific CD8+ T cells in RMs with full

cART

suppression of SIV

viremia

SIV-specific CD8+ T cells co-express TIGIT & PD-1

Slide5

TIGIT+ CD8+ T cells produce less

IFNγ

when stimulated

Single and dual blockade of PDL1 and TIGIT restores CD8+ T cell

proliferation

Summary

TIGIT is expressed on SIV-specific CD8+ T cells and proliferative capacity can be restored with single or dual blockade

Rhesus TIGIT in SIV infection recapitulates what is observed with human TIGIT in HIV infection

Glen Chew (TUAA02

Rm

211-214)

TIGIT/PD1 blockade could be used in conjunction with “shock and kill” approaches

Slide6

Acknowledgements

Oregon Health & Science University

Jonah SachaBenjamin BurwitzShaheed AbdulhaqqHelen WuJason ReedKatherine HammondReesab Pathak Scott Hansen

University of HawaiiLishomwa NdhlovuGlen Chew – TUAA02Tsuyoshi FujitaBristol-Myers SquibbAlan KormanMark Maurer