PPT-1 The Aldol Condensation Reaction

Preparation of Benzalacetophenon Chalcones 2 Are enone or α β unsaturated aromatic ketones containing the reactive keto ethylene group CO CHCH Many of the chalcones are highly biological active which have medicinal and pharmaceutical applications. But reaction can be engineered to force aldol product Enolate can be formed transiently as above or uantitativel e w LDA an unsaturated ketone qy In base alone reaction stops at alcohol In base and heat aldol is dehydrated loses H O The Aldol Co Th is makes the aldol reaction an important reaction for organic synthesis Origina lly the al dol reaction used ethanal see below and the refore the product contained both an ald ehyde and an alcoh ol functional group thus it became known as the al 18-4. Alkylation of enolates can be difficult to control.. The alkylation of an aldehyde or ketone enolate is an example of a nucleophilic substitution reaction.. The alkylation of aldehydes and ketones is complicated by several unwanted side reactions.. Malcolm Thornton. Managing Director, Proten Services. What is the PCA?. The Property Care Association (PCA) is the trade association representing members, promoting best practice and providing technical guidance in the following sectors:. 1. Chapter 19. Condensation and Conjugate Addition Reactions of Carbonyl . Compounds. More Chemistry of Enolates. Ch. . 19 . - . 2. About The Authors. . These PowerPoint Lecture Slides were created and prepared by Professor William Tam and his wife, Dr. Phillis Chang. . Organic compounds contain . carbon. and are found in living things. (Except hydrogen carbonates, e.g. sodium hydrogen carbonate, carbonates, e.g. calcium carbonate and oxides of carbon, e.g. carbon dioxide). , •AJLn equLOLrLum etZeen Netone nd OdoO OLes •,n cLd Oone rectLon stops t OcoKoO.•,n cLd completed. B) IF the side with the enolate is favored (by using a very strong base like LDA), adding too much can stop the reaction. For example, if 1.0 equivalent of LDA is used, the entire sample Grace College. Chapter . 22. Lecture. Organic Chemistry. , . 9. th. Edition. L. G. Wade, Jr.. Condensations and Alpha Substitutions of Carbonyl Compounds. © 2017 Pearson Education, Inc.. Alpha Substitution. . 73. April. . 25, . 2011. . . -H Reactivity . (J&F Ch. 19). Condensations . (J&F Ch. 19). Fischer’s Glucose Proof - Introduction. . This. For copyright notice see final page of this file. Introduction. The acidity of organic compounds is often determined . by . neighboring groups because . they . can help stabilizing . the . resulting anion (i.e., halogen, nitro, etc.) because of . their . a. -carbon and . b. -carbon of Carbonyl Compounds. (Chapters . 18 & . 19). . Qualitative . Iodoform. Test . for methyl ketones. 1. In this chapter . :. Reactions that derive from the weak acidity of hydrogen atoms on carbon atoms adjacent to a carbonyl group. These hydrogen atoms are call the . The term alcohol is applied to . all . organic compounds whose . molecules contain hydroxyl . group, . —. OH, attached to a saturated carbon atom. .. The general formula is R-OH, . R- Alkyl group. - OH - the functional group of alcohol. Lesson 1. (b) the concept of . monomers. and . polymers. and the importance of . condensation. and . hydrolysis. reactions in a range of biological molecules . (. c) the chemical elements that make up biological molecules .