PPT-Aplastic anaemia and bone marrow failure

Pancytopenia Pancytopenia is a reduction in the blood count of all the major cell lines red cells white cells and platelets It has several causes which can be broadly divided into decreased bone marrow . G. enetics. Priyanca. Patel and James Fox. What is pre-implantation genetic diagnosis (PGD)?. . PGD . enables . people with an . inheritable condition. . in their family to avoid . passing it on . Agenda. 1.. 2.. 3.. 4.. Introduction. Introduction to Aplastic Anemia, its risk factors and epidemiolog. y . Mechanism . Look at the pathophysiology and the diagnosis of the disease . Next Steps. Take a closer look at research that is being done . Brian Boulmay. , . MD. Bone Marrow Failure . Ineffective marrow-poeisis is the final endpoint of many diseases. . Congenital. Acquired . Genetic. Environmental or iatrogenic causes. Congenital marrow failure can present at any age.. Aplastic Anemia . Alternate names for disorder: Aplastic Anemia . Names pronounced: A-Plasic A- Nemia . How the name was chosen: The name was chosen because aplastic means failure of organ or tissue and anemia means blood disorder, so therefore it makes aplastic anemia.. MBBS, DMU, MD, PhD. Associate Professor, Cardiology. College of Medicine, ALJOUF University, KSA. Outlines. HAEMOLYTIC ANAEMIA. APLASTIC ANAEMIA . SICKLE-CELL ANAEMIA . HAEMOLYTIC ANAEMIA. Haemolytic Anaemia . Josu. de la . Fuente. Departments of Paediatrics and Haematology. Imperial College London. 25% of paediatric and 10% of young adult patient presenting with aplastic anaemia. Fanconi Anaemia. Median age of presentation 7 years of age. Lauren . Cosolo. , RN, BScN, MN. Outline. Review bone marrow failure and disease. Discuss . Myelodysplastic. syndrome, pathophysiology, clinical presentation, diagnosis, treatment. Discuss Aplastic Anemia, . Dr. M. Sabloff. Director of the Leukemia Program at the Ottawa Hospital. October 13. th. 2018. Disclosures . Objectives. Aplastic anemia. Epidemiology. Treatment options. P. NH. Epidemiology. Treatment. (PNH). PNH. is . a rare, acquired, . clonal. disorder of marrow stem cells . in which . there . is. . deficient synthesis of . the . glycosyl-phosphatidyl-inositol. (GPI. ) anchor, a structure that attaches . The Focus section seeks to publish relevant and timely continuingeducation for clinical laboratory practitioners. Section editors, topics,and authors are selected in advance to cover current areas of anaemia. Assist.Prof. . :. Dr.Maysem. M. . Alwash. . Erythropoiesis. is the generation of red blood cells . .. .. -. All the circulating blood cells derive from . pluripotential. stem . cells in the marrow. One of the most common . anaemias. occurs in patients with . a variety of chronic inflammatory and malignant diseases. The characteristic features. 1 . Normochromic. , . normocytic. or mildly . hypochromic. MD. ASSTT. PROFESSOR. DEPTT. OF MEDICINE. Aplastic. anemia is . pancytopenia. with bone marrow . hypocellularity. .. M. en and women are affected with equal frequency.. A. ge distribution is biphasic, with the major peak in the teens and twenties and a second rise in older adults.. JR2, GENERAL MEDICINE. TDMCH. BONE MARROW FAILURE SYNDROMES . HYPOPROLIFERATIVE ANEMIA . APLASTIC ANEMIA. MYELODYSPLASTIC SYNDROME. PURE RED CELL APLASIA. MYELOPHTHISIS. APLASTIC ANEMIA: DEFINITION. PANCYTOPENIA + BM HYPOCELLULARITY.