PPT-Treatment of Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Dr M Sabloff Director of the Leukemia Program at the Ottawa Hospital October 13 th 2018 Disclosures Objectives Aplastic anemia Epidemiology Treatment options P NH Epidemiology Treatment. Hinkle & . cheever. ch33. Physiology review: . Hematologic . System. Consists of blood . and the blood forming . sites. . Blood: . Plasma. : fluid portion of . blood—contains platelets and clotting factors. J. Christian Barrett, MD. Pathophysiology of PNH. Paroxysmal Nocturnal . Hemoglobinura. A disease of the hematopoietic stem cell. Non-malignant . clonal. disease. Defective post-translational processing of . Introduction. Epidemiology . Drug-induced Aplastic anemia. Drug-induced Hemolytic anemia. Drug-induced Neutropenia and Agranulocytosis. Drug-induced Thrombocytopenia. Drug-induced Megaloblastic anemia. Agenda. 1.. 2.. 3.. 4.. Introduction. Introduction to Aplastic Anemia, its risk factors and epidemiolog. y . Mechanism . Look at the pathophysiology and the diagnosis of the disease . Next Steps. Take a closer look at research that is being done . Brian Boulmay. , . MD. Bone Marrow Failure . Ineffective marrow-poeisis is the final endpoint of many diseases. . Congenital. Acquired . Genetic. Environmental or iatrogenic causes. Congenital marrow failure can present at any age.. Aplastic Anemia . Alternate names for disorder: Aplastic Anemia . Names pronounced: A-Plasic A- Nemia . How the name was chosen: The name was chosen because aplastic means failure of organ or tissue and anemia means blood disorder, so therefore it makes aplastic anemia.. Allyson Pishko, MD MSCE. Assistant Professor. November 13, 2021. Disclosures. Research funding:. . Sanofi Genzyme. Outline. Paroxysmal Nocturnal . Hemoglobinura. (PNH). How? . Why. ?. Diagnosis. Signs/symptoms of PNH. 1- what is the mode of inheritance in the vast majority f spherocytosis cases?. Autosomal dominant. Autosomal recessive. X-linked dominant. X linked recessive. 2- The amino acid present at the sixth position of the normal alpha-globin chain is replaced by which one of the following amino acids in sickle cell disease?. 35 The prevalence of aplastic anemia following pregnancy is rare. Pegnancy associated with aplastic anemia is fortu-nately more uncommon considering the significant morbidity and mortality for both mo The Focus section seeks to publish relevant and timely continuingeducation for clinical laboratory practitioners. Section editors, topics,and authors are selected in advance to cover current areas of 19/02/2015. Khalid Al-. Anazi. Cytopenias. ** . Low WBC counts:. . - . Neutropenia - . Lymphocytopenia. - . Monocytopenia. ** . Low . Hb. level:. . - Normocytic Anemia - Microcytic Anemia - Macrocytic Anemia. MD. ASSTT. PROFESSOR. DEPTT. OF MEDICINE. Aplastic. anemia is . pancytopenia. with bone marrow . hypocellularity. .. M. en and women are affected with equal frequency.. A. ge distribution is biphasic, with the major peak in the teens and twenties and a second rise in older adults.. Anna Koget, D.O. . Aplastic Anemia . An . acquired. stem cell disorder . Idiopathic (unknown etiology) in 70% of the cases . Diagnosis of exclusion . Important to differentiate from other causes of Bone Marrow Failure . JR2, GENERAL MEDICINE. TDMCH. BONE MARROW FAILURE SYNDROMES . HYPOPROLIFERATIVE ANEMIA . APLASTIC ANEMIA. MYELODYSPLASTIC SYNDROME. PURE RED CELL APLASIA. MYELOPHTHISIS. APLASTIC ANEMIA: DEFINITION. PANCYTOPENIA + BM HYPOCELLULARITY.