PPT-Understanding PNH The Aplastic Anemia and MDS International Foundation

Allyson Pishko MD MSCE Assistant Professor November 13 2021 Disclosures Research funding Sanofi Genzyme Outline Paroxysmal Nocturnal Hemoglobinura PNH How Why Diagnosis Signssymptoms of PNH. Apoptosis. Differentiation. Asymptomatic,IPSS. low . Low/Int-1. Symptomatic,IPSS. Int-2/High Risk. BM function. Greenberg, Blood 1997, . Malcovati,JCO. 2009,Greenberg . Blood 2012. Transfusion. Transfusio. The Royal Lancaster. London . 43. rd. October 2014. . Welcome to. MDS UK Patient Support Group. . Patient and Family Forum. Agenda. 10.30. . Welcome and Introduction to MDS UK. . Sophie Wintrich, Chief Executive/Patient Liaison, MDS UK. Brian Boulmay. , . MD. Bone Marrow Failure . Ineffective marrow-poeisis is the final endpoint of many diseases. . Congenital. Acquired . Genetic. Environmental or iatrogenic causes. Congenital marrow failure can present at any age.. Stockholm, Sweden, 27 October 2020 Sobi and Apellis enter collaboration for global co - development and ex - US commerciali s ation of s ystemic p egcetacoplan in rare diseases with urgent ne a pathophysiological condition in which the body cannot meet its demands for oxygen. . M: . Hb. <13.5 . Hct. <41 . F. : . Hb. <12 . Hct. <36 . Erythrocyte Indices . Hgb. M: 14.0-18.0 . .. Epidemiology.. Classification.. Review the terminology used to discuss anemia.. Evaluation:. .. . • Address clues in the history and exam that can direct the evaluation. . • Describe one approach to using lab tests to make the diagnosis. . Pancytopenia. Pancytopenia. . is a reduction in the blood count of all the major. cell lines – red cells, white cells and platelets. It has several causes. which . can be broadly divided into . decreased bone marrow . Dr. M. Sabloff. Director of the Leukemia Program at the Ottawa Hospital. October 13. th. 2018. Disclosures . Objectives. Aplastic anemia. Epidemiology. Treatment options. P. NH. Epidemiology. Treatment. 35 The prevalence of aplastic anemia following pregnancy is rare. Pegnancy associated with aplastic anemia is fortu-nately more uncommon considering the significant morbidity and mortality for both mo The Focus section seeks to publish relevant and timely continuingeducation for clinical laboratory practitioners. Section editors, topics,and authors are selected in advance to cover current areas of Mikkael A. Sekeres, MD, MS. Professor of Medicine. Director, Leukemia Program. Vice Chair for Clinical Research. Cleveland Clinic. Cleveland, Ohio. David P. Steensma, MD, FACP. Associate Professor of Medicine. MD. ASSTT. PROFESSOR. DEPTT. OF MEDICINE. Aplastic. anemia is . pancytopenia. with bone marrow . hypocellularity. .. M. en and women are affected with equal frequency.. A. ge distribution is biphasic, with the major peak in the teens and twenties and a second rise in older adults.. Anna Koget, D.O. . Aplastic Anemia . An . acquired. stem cell disorder . Idiopathic (unknown etiology) in 70% of the cases . Diagnosis of exclusion . Important to differentiate from other causes of Bone Marrow Failure . JR2, GENERAL MEDICINE. TDMCH. BONE MARROW FAILURE SYNDROMES . HYPOPROLIFERATIVE ANEMIA . APLASTIC ANEMIA. MYELODYSPLASTIC SYNDROME. PURE RED CELL APLASIA. MYELOPHTHISIS. APLASTIC ANEMIA: DEFINITION. PANCYTOPENIA + BM HYPOCELLULARITY.