Personalized Therapy  in Relapsed or Refractory CLL
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Personalized Therapy in Relapsed or Refractory CLL

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Personalized Therapy in Relapsed or Refractory CLL




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Presentation on theme: "Personalized Therapy in Relapsed or Refractory CLL"— Presentation transcript:

Slide1

Personalized Therapy in Relapsed or Refractory CLL

Slide2

Slide3

Slide4

IWCLL Criteria for Treating CLL

Slide5

Other Considerations at Relapse

Slide6

Risk Factors at Relapse

Slide7

IGHV

Status Affects Clinical Course

Slide8

Case 1: 65-Year-Old Man

Slide9

Assessing This Patient's Options

Slide10

TP53 Mutation/del(17p) and CIT

Slide11

Monoclonal Antibodies and del(17p)

Slide12

Efficacy of Ibrutinib in del(17p)

Slide13

Safety of Ibrutinib

Slide14

Additional Considerations for Novel Agents

Slide15

Overall Findings From RESONATE

Slide16

Efficacy of Venetoclax in del(17p)

Slide17

Safety of Venetoclax in Phase 2 Trial

Slide18

TLS With Venetoclax

Slide19

PI3K-δ Inhibitor Idelalisib

Slide20

Case 2: 43-Year-Old Man

Slide21

Considerations for Sequencing Therapy

Slide22

Investigational Agents for Refractory CLL

Slide23

Additional Considerations for Sequencing Therapy

Slide24

Minimal Residual Disease

Slide25

Case 3: 77-Year-Old W

oman

Slide26

Assessing This Patient's Options

Slide27

Prolonged Lymphocytosis

Slide28

Summary of Safety Concerns With Novel Agents

Slide29

Concluding Remarks

Slide30

Abbreviations

Slide31

Abbreviations (cont)

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Abbreviations (cont)

Slide33

Abbreviations (cont)