PPT-Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

ASH Review 2012 Stephen Spurgeon spurgeosohsuedu Disclosures Speakers Bureau GSK Millenium Cephalon CLL Pertinent Topics ASH treatment updates James DF et al ASH 2011 Abstract 291. Lymphoma is divided into two major categories Hodgkin lymphoma HL and nonHodgkin lymphoma NHL Mantle cell lymphoma MCL is one of about 70 di64256erent subtypes of NHL Lymphoma may arise in any one of three types of lymphocytes B lymphocytes B cells New agents timing?. Agne Paner, MD. Assistant professor of Medicine. RUSH University Medical Center. Blood Smear in CLL. Chronic Lymphocytic Leukemia. Most prevalent type of adult leukemia . 30% of all . CLL/SLL. Use of Markers in Nonclinical Trial Practice. CLL/SLL. Frontline Therapy. CLL/SLL. Second-line Therapy. CLL/SLL. Cure vs Indefinite Therapy. CLL/SLL. CART-19 Therapy. Spring 2010. Clinical history. A 62 year old man presents to his primary care physician with lymphadenopathy. . A CBC demonstrates the following: . WBC 20.73 thousand cell/microliter . 12% neutrophils. is the most common type of . leukemia. . . CLL involves a particular subtype of white blood cells, which is a . lymphocyte. called a . B cell. . . . The . definition of CLL includes >5000 CLL-phenotype . a closer look . SEER HEMATOPOIETIC DATABASE. Understanding the disease. AMBIGUOUS TERMS. Choosing . the right . Histology & TOPO CODE . Navigation of the Hematopoietic and Lymphoid Neoplasm Database . T-cell Neoplasms Chronic Myelomonocytic Leukemia ASXL1Juvenile Myelomonocytic Leukemia PTPN11 disease or mutation Germline CBL mutation Myeloid/Lymphoid Neoplasms PDGFRA rearrangement often del4q12q1 Mehrdad. . Payandeh. Department of Hematology and Oncology,. . Kermanshah University of Medical Sciences, Kermanshah, Iran . August 18-19, 2016 London, UK. . Faculty. Edris. . Sadeghi. , . MSc. in the marrow to mature or may travel to other parts of the body to mature. Normally, ontrolled way, as the body needs them. Some and lymph vessels. Some reside in the lymphatic tissues that are prim E4 I CUTIS ® of mature T lymphocytes associated with infection by human T-lymphotropic virus 1 (HTLV-1), which is increasing in incidence in areas of the United States with large immigrant popula Overview Case 3 • 59 year old man with lymphadenopathy in the neck, supraclavicular area, inguinal area . He states that he has had LN for at least 18 months and they have waxed and waned . Sri . Venkateswara. Institute of Medical Sciences. Tirupathi. . . ALL AND CLL/SLL. . ACUTE LYMPHOBLASTIC LEUKEMIA. Primarily a disease. . of children. Age -. Majority occur between 1-5 . yrs. ( second peak in adults between 30-40 . Introduction to Leukemia. Definition. Historic Perspective. Etiology and Risk Factors . Incidence. Classification. Comparison of Acute and Chronic Leukemia. Leukemia. Definition. Leukemia is a malignant disease of hematopoietic tissue characterized by the accumulation abnormal white cells (neoplastic or leukemic) in the bone marrow leading to bone marrow failure, a raised circulating white cell count (leukocytosis) and infiltrate organs (e.g liver, spleen, lymph nodes, brain) . Dr Mona Yuklea. Hematology Department, Meir Hospital, 2019. CLL - incidence. The most common leukemia among adults in Western Countries. 4-6 cases /100000 person/year. At diagnosis. More than 70% of patients – older than 65 y.