Launch Symposium 6 June 2013 Imperial College St Marys Campus Rothschild Lecture Hall School of Medicine Norfolk Place London Maternal and Child Undernutrition and Overweight in Lowand MiddleIncome Countries ID: 708108
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Slide1
The Lancet Series on Maternal and Child Nutrition
Launch Symposium
6 June, 2013
Imperial College – St Mary’s Campus
Rothschild Lecture Hall, School of Medicine
Norfolk Place, LondonSlide2
Maternal and Child Undernutrition and Overweight in Low-and Middle-Income Countries:
Prevalences
and
Consequences
Robert E Black
1
, Cesar G Victora2, Susan P Walker3, Zulfiqar A Bhutta4
, Parul Christian1, Mercedes de Onis5, Majid Ezzati6, Sally Grantham-McGregor3,7
, Joanne Katz1, Reynaldo Martorell8, Ricardo Uauy9 and the Maternal and Child Nutrition Study Group
1 Johns Hopkins University 2 Universidad de Federal de Pelotas3 The University of the West Indies4
The Aga Khan University and Medical Center
5 World Health Organization6 Imperial College of London7 University College London8 Emory University9 London School of Hygiene and Tropical Medicine Slide3
Series Background
2008 Series identified need to focus on critical period during pregnancy and first two years of life, the 1,000 days in which good nutrition and healthy growth have lifelong
benefits2008 Series also called for greater priority for national nutrition programmes, stronger integration with health programmes, enhanced inter-sectoral approaches and more focus and coordination in the global nutrition system
Five years on, we re-evaluate problems of maternal and child undernutrition, consider growing problem of overweight and obesity for women and children and assess the current and needed national and global response
2008 Series Executive Summary
3Slide4
Series Overview
Paper 1: prevalence and consequences of nutritional conditions during life course from adolescence (for girls) through pregnancy to childhood and implications for adult health
Paper 2: evidence supporting nutrition-specific interventions, health impact and cost of scaling upPaper 3: nutrition-sensitive interventions and approaches and their potential to improve nutrition
Paper 4: the features of an enabling environment for nutrition and how they can be favourably influenced
Comment: examines what is currently being done, and what should be done nationally and internationally
Insert Series cover/exec summary
2013 Series Executive Summary
4Slide5
Framework for
Actions to Achieve Optimum Fetal and Child Nutrition and Development
5Slide6
Adolescent NutritionSlide7
Adolescent Nutrition: Important for Girls,
and for the Future Generation
As many as half of all adolescent girls in some countries are stunted, increasing risk of
complications in pregnancy and delivery and of poor fetal growth 7Slide8
Maternal
NutritionSlide9
9
Trends in
Thinness
and Obesity for Women Aged 20-29
Years in UN Regions and Globally (
1980-2008)
Prevalence of low
BMI
in adult women has decreased in Africa/Asia since 1980, but remains higher than 10%
Maternal overweight and obesity has increased steadily since 1980;
resulting in increased maternal morbidity and infant mortalitySlide10
Prevalence of V
itamin A and Iodine Deficiencies, Inadequate Zinc Intake, and Iron Deficiency Anaemia
10Slide11
Iron and Calcium Deficiencies Contribute to Maternal Deaths
Series confirms anaemia is a risk factor for maternal deaths, most likely due to haemorrhage, the leading cause of maternal deaths (23% of total deaths)
Calcium deficiency increases the risk of pre-eclampsia, currently the second leading cause of maternal death (19% of total deaths)11
Addressing these deficiencies could result in substantial reduction of maternal deathsSlide12
Evidence
Highlights Importance of Nutritional Status in Women Before and During PregnancyShort maternal stature may lead to obstructed labour and maternal and fetal or neonatal deathMaternal
stunting and low Body Mass Index increases the risk of fetal growth restriction (small for gestational age)Maternal obesity leads to gestational diabetes, pre-eclampsia, haemorrhage and higher risk of neonatal and infant death
12Slide13
Prevalence of SGA Births
32.4 million babies were born SGA in 2011; 27% of all births in LMICs
13Slide14
Risks of SGA for Mortality and Preterm Birth for Neonatal Mortality
14
Reductions in child mortality could be achieved by targeting interventions to reach babies born too small or too soonSlide15
Risk of SGA for Stunting
15
20% of stunting by
24 months can be attributed to being SGASlide16
Child NutritionSlide17
Stunting Rate is Slowly Decreasing
Figure 417
165 million children under five are stunted (25.7%)
2.1%
annual rate of reduction is not fast enough to reach WHA target Slide18
Prevalence of Wasting and Severe Wasting in Children <5 Years Old by UN Regions, 2011
52 million children under 5 are
wasted,
19 million severely wasted
18Slide19
Child Obesity on the Rise
19Slide20
Micronutrient Deficiencies
Deficiencies of essential vitamins and minerals continue to be widespread and have significant adverse effects on child survival and development, as well as maternal healthDeficiencies of vitamin A and zinc adversely affect child health and survival, and deficiencies of iodine and iron, together with stunting, contribute to children not reaching their developmental potential
Significant progress has been made in addressing vitamin A deficiency but efforts must continue at current coverage levels to avoid backsliding because dietary intake of vitamin A is still inadequate
20Slide21
When
Coupled with Infectious Diseases, Wasting Increases Hazard of Death21
NEED TO INSERT
Weight-for-Length
Z-ScoreAll Deaths
HR (95% CI)
Pneumonia DeathsHR
(95% CI)Diarrhoea Deaths
HR (95% CI)
Measles Deaths HR
(95% CI)Other Infectious DeathsHR
(
95% CI)< -311.6 (9.8, 13.8)
9.7(
6.1, 15.4
)
12.3
(
9.2, 16.6)
9.6
(
5.1, 18.0)
11.2
(
5.9, 21.3)
-3 to < -2
3.4
(
2.9, 4.0
)
4.7
(
3.1, 7.1)
3.4
(
2.5, 4.6)
2.6
(
1.3, 5.1)
2.7
(
1.4, 5.5)
-2 to < -1
1.6
(1.4
, 1.9
)
1.9
(
1.3, 2.8)
1.6
(
1.2, 2.1)
1.0
(
0.6, 1.9)
1.7
(
1.0, 2.8)
≥
-
1
1.0
1.0
1.0
1.0
1.0Slide22
When
Coupled with Infectious Diseases, Stunting Increases Hazard of Death22
NEED TO INSERT
Height/Length-for-Age
Z-ScoreAll Deaths
HR (95% CI)
Pneumonia DeathsHR (95% CI)
Diarrhoea Deaths HR
(95% CI)
Measles Deaths HR (
95% CI)Other Infectious DeathsHR (95% CI)
< -3
5.5 (4.6, 6.5) 6.4
(4.2, 9.8) 6.3
(
4.6, 8.7)
6.0
(
3.0, 12.0)
3.0
(
1.6, 5.8)
-3 to < -2
2.3
(
1.9, 2.7)
2·2
(
1.4, 3.4)
2.4
(
1.7, 3.3)
2.8
(
1.4, 5.6)
1.9
(1.0
, 3.6)
-2 to < -1
1.5
(1.2, 1.7)
1.6
(
1.0, 2.4)
1.7
(
1.2, 2.3)
1.3
(
0.6, 2.6)
0.9
(
0.5, 1.9)
> -1
1.0
1.0
1.0
1.0
1.0Slide23
Prevalence of Stunting and Overweight for Highest and Lowest Wealth Quintiles in Selected Countries
23Slide24
Breastfeeding Practices by UN Region During 2000-2010
24
Exclusive
breastfeeding only about 30% or less in major UN regionsSlide25
Child Mortality Due to Nutritional Disorders
25
Nutritional Disorders
Attributable deaths with UN prevalences*
Proportion of total deaths of children younger than 5 years
Fetal growth restriction (<1 month)
817,000
11.8%
Stunting (1-59 months)
1,017,000*
14.7%
Underweight (1-59 months)
999,000*
14.4%
Wasting (1-59 months)
Severe
Wasting (1-59 months)
875,000*
516,000*
12.6%
7.4%
Zinc deficiency (12-59 months)
116,000
1.7%
Vitamin A deficiency (6-59 months)
157,000
2.3%
Suboptimum breastfeeding (0-23
months)
804,000
11.6%
Joint effects of fetal growth restriction and
suboptimum breastfeeding in neonates
1,348,000
19.4%
Joint effects of fetal growth restriction, suboptimum
breastfeeding, stunting, wasting, and vitamin A and zinc deficiencies (<5 years)
3,097,000
44.7%
Data are to the nearest thousand. *Prevalence estimates from the UN.Slide26
Child Deaths Attributed to Nutritional Conditions
Undernutrition (fetal growth restriction, sub-optimal breastfeeding, stunting, wasting and deficiencies of vitamin A and zinc) is responsible for 45% of all under five child deaths, representing more than 3 million deaths each year (3.1 million of the 6.9 million child deaths in 2011)
Fetal growth restriction and sub-optimal breastfeeding together are responsible for more than 1.3 million deaths, or 19.4% of all under five child deaths, representing 43.5% of all nutrition-related deaths Deficiencies of vitamin A and zinc are responsible for nearly 300,000 child deaths
26Slide27
Paper 1 Key Messages
Short stature, low BMI and vitamin and mineral deficiencies in pregnancy contribute to maternal morbidity and mortality, fetal growth restriction, infant mortality and stunted growth and development Stunting of growth in the first 2 years of life affects 165 million children who have elevated risk of mortality, cognitive deficits and increased risk of adult obesity and non-communicable diseases
Vitamin A and zinc deficiencies in young children increase the risk of death from infection and other micronutrients have important developmental consequencesThis new evidence strengthens the case for a continued focus on the critical 1,000 day window during pregnancy and the first two years of life, highlighting the importance of intervening early in pregnancy and even prior to conception
27