Update From the NIMH Joshua A. Gordon, M.D., Ph.D.
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Presentation on theme: "Update From the NIMH Joshua A. Gordon, M.D., Ph.D."— Presentation transcript:
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Update From the NIMH
Joshua A. Gordon, M.D., Ph.D.
Director, NIMH
July 1, 2017
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About the NIMH Director
Director’s Research Priorities
Current State of NIMHScience Highlights and UpdatesParticipation in ResearchFuture Directions
Welcome
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About the NIMH Director
Director’s Research Priorities
Current State of NIMH
Science Highlights and Updates
Participation in Research
Future Directions
Introduction
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University of California, San Francisco
Received dual M.D./Ph.D.
Pioneered methods to study brain plasticity in miceColumbia University Psychiatry residency, neuroscience fellowshipJoined Department of PsychiatryDirector of the Columbia University/New York State Psychiatric Institute Adult Psychiatry Residency Program
Research focus on neural activity in mice carrying mutations of relevance to psychiatric disease
Maintained psychiatric practice, caring for patients who suffer from the illnesses studied in the lab
Universal Screening Plus Intervention Reduces Number of Suicide Attempts
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Miller…ED-SAFE Investigators,
JAMA Psychiatry
, 2017
Intervention led to a 30% decrease in suicide attempts over the 52-weeks follow-up, as compared to standard emergency treatment care
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2016
Science Highlight:
Tracking Disparities in Access to Care
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http://hcsrn.org/mhrn/en/ResearchProjects/
MHRN is the nation’s preeminent source of population-based research on mental health, partnering with 13 health system research centers that provide care of a diverse population of over 12.5 million people in 15 states
(1)
Mental Health Research Network (MHRN)
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Karen Coleman, Greg Simon et al, 2016, Psychiatric Services
Coleman…Simon,
Psychiatric Services
, 2016
Are Racial-Ethnic Differences in Psychiatric Diagnosis and Treatment Present in Health Care Systems Across the US?
(n= 7.5 million adults)
Racial-Ethnic Differences in
Psychiatric Diagnosis and Treatment
Racial-ethnic differences in the diagnosis and treatment of psychiatric conditions persist, especially for Blacks
Blacks were nearly twice as likely as Whites to receive a diagnosis of Schizophrenia
Depression and anxiety diagnoses were lower among racial-ethic minorities compared to non-Hispanic Whites
Exception: Native American and Alaskan Native groups had similar rates as Whites
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Science Highlight:
Brief Therapy for Pediatric Anxiety and Depression
2017
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Clinical Trial of Children andAdolescents with Depression or Anxiety
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Weersing…Iyengar,
JAMA Psychiatry
, 2017
Enrolled 185 children and adolescents (ages 8 – 16) with depression or an anxiety disorder
Random assignment to assisted referral care (ARC) or brief behavioral therapy (BBT)
BBT
addressed both depression and anxiety using a streamlined approach
Children and adolescents in the BBT group showed greater improvement than those in the ARC group
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Striking Benefits for Hispanic Children and Adolescents
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Hispanic youth who received BBT showed the greatest improvement and performed best on measures of functioning
Weersing…Iyengar,
JAMA Psychiatry
, 2017
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About the NIMH Director
Director’s Research Priorities
Current State of NIMH
Science Highlights
Participation in Research
Big Data Approaches
All of Us Cohort
Future Directions
Active Participation in Research
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Big Data Approach to
Identifying Depression Subtypes
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Patterns of Resting State Connectivity
Drysdale…Liston,
Nature Medicine
, 2017
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Clustering Patients Based on Connectivity
*
Drysdale…Liston,
Nature Medicine
, 2017
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Subtypes Differ in Clinical Dimensions
Drysdale…Liston,
Nature Medicine
, 2017
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Subtypes Differ in Responsivity to Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation
Drysdale…Liston,
Nature Medicine
, 2017
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NIH All of Us Research Program
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Historic effort to gather data from one million or more people in the U.S.
Focus on individual differences in lifestyle, environment, and biology
Paving the way toward precision medicine
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About the NIMH Director
Director’s Research Priorities
Current State of NIMH
Science Highlights
Participation in Research
Future Directions
Moving Forward
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Prioritize excellent science, and within the realm of excellent science, diversity.
Focus on learning and working closely with all of you to gain insight that can help inform the future directions of our research programs.
Address challenges facing NIMH.Think more broadly about neuroscience, psychiatry, and public health.Help build momentum towards treatments that can change the lives of individuals, families, and communities affected by mental disorders.
