PPT-Eicosanoids ( Prostaglandins, Leukotrienes) and Platelet Activating Factor

SUHAS AGEY Asst professor Dept of Pharmacology Hrpiper Shirpur Contents Introduction Chemistry biosynthesis COX pathways Prostaglandins Classification Pcological and patho role. Thrombocytes. Platelets (Thrombocytes). 2- 4 micromillimeters in diameter. 250,000 – 400,000 per microliter . (too few thrombocytopenia – too many thrombocytosis). Lifespan on average 6 – 10 days. 1. Dr. Nikhat Siddiqi. Prostaglandins, and the related compounds . thromboxanes. and . leukotrienes. , are collectively known as . eicosanoids. to reflect their origin from polyunsaturated fatty acids with 20 carbons. . UNIT III:. Lipid Metabolism. Part 3. Prostaglandins. , and the related compounds . thromboxanes. and leukotrienes, are collectively known as eicosanoids to reflect their origin from polyunsaturated fatty acids with 20 . Thrombocytes. Platelets (Thrombocytes). 2- 4 micromillimeters in diameter. 250,000 – 400,000 per microliter . (too few thrombocytopenia – too many thrombocytosis). Lifespan on average 6 – 10 days. Prof. S. . Kajuna.  . The . prostaglandins. are a group of . lipid. compounds that are derived . enzymatically. from . fatty acids. and have important functions in the . animal. body. Every prostaglandin contains 20 . Sulistyo. . Rini. , . MSc. Five Stages of . Hemostasis. Vessel spasm. Formation of the platelet plug. Blood coagulation or development of an insoluble fibrin . clot. Clot retraction . Clot dissolution . Dr. . Haitham. M. Al-. Wali. P. h. .D. Pharmacology. 22 February 2018. 1. PROSTAGLANDINS. The NSAIDs act by inhibiting the synthesis of prostaglandins. Thus, an . understanding of . NSAIDs requires comprehension of the actions and . PGs, TXs, LTs). Objectives:. . Discover and distinguish relationships between . different types of eicosanoid molecules . (PGs, TXs, LTs). Gain knowledge of enzymes that create PGs . and TXs (COX-1 and -2). Hematology Oncology Fellow. Hemostasis. Process of blood clot formation at site of vessel injury. Response must be. Quick. Localized. Carefully regulated. Phases of hemostasis. Formation of platelet plug. is a Generic term for the 20 Carbon related compounds like:. Prostaglandins (PGs). Prostacyclins (PGI2). Thromboxanes (TX). Leukotrienes (LT). Lipoxins (LX). Resolvins. Eoxins. Biosynthesis Of Eicosanoids. Eicosanoids. Several Classes of Signal Molecules:. . P. rosta. g. landins, Thromboxanes, Leukotrienes. Produced In Almost all Tissues. Wide Range of Responses. Local Hormones. Very Potent. Short Half Life . Acids & . Eicosanoids. BIOMEDICAL IMPORTANCE. Unsaturated fatty acids in phospholipids of the cell. membrane are important in maintaining membrane. fluidity. A high ratio of polyunsaturated fatty acids to. Alaraji. B.D.S.F.I.B.M.S. These are conditions that alter ability of blood vessels, platelet, and coagulation factors to maintain homeostasis. Inherited bleeding disorder are genetically transmitted while acquired bleeding disorders occur as the result of diseases that affect vascular wall integrity, platelets, coagulation factors, and drugs which cause bleeding, radiation, or chemotherapy for treatment of cancer also result in bleeding problems . . and . congestion. both. . refer. to an . increase. in . blood. volume . within. a . tissue. , . but. . have. . different. . underlying. . mechanisms. .. Hyperemia. . is. . an. . active. .