PPT-THE EICOSANOIDS: PROSTAGLANDINS, THROMBOXANES, LEUKOTRIENES, & RELATED COMPOUNDS

Dr Haitham M Al Wali P h D Pharmacology 22 February 2018 1 PROSTAGLANDINS The NSAIDs act by inhibiting the synthesis of prostaglandins Thus an understanding of NSAIDs requires comprehension of the actions and . 1. Dr. Nikhat Siddiqi. Prostaglandins, and the related compounds . thromboxanes. and . leukotrienes. , are collectively known as . eicosanoids. to reflect their origin from polyunsaturated fatty acids with 20 carbons. . UNIT III:. Lipid Metabolism. Part 3. Prostaglandins. , and the related compounds . thromboxanes. and leukotrienes, are collectively known as eicosanoids to reflect their origin from polyunsaturated fatty acids with 20 . Prof. S. . Kajuna.  . The . prostaglandins. are a group of . lipid. compounds that are derived . enzymatically. from . fatty acids. and have important functions in the . animal. body. Every prostaglandin contains 20 . Dr. Arthur Roberts. Modified from course of Dr. Warren Beach. Materials. ELCnew. pharmwiki.org. updated lectures. Notes on the updates. class notes from the current lectures. lectures and notes from previous years. Michael O. Rodgers, Ph.D.. Regents Researcher and Adjunct Regents Professor. School of Civil and Environmental Engineering and School of Public Policy. Georgia Institute of Technology. Atlanta, GA 30332. PGs, TXs, LTs). Objectives:. . Discover and distinguish relationships between . different types of eicosanoid molecules . (PGs, TXs, LTs). Gain knowledge of enzymes that create PGs . and TXs (COX-1 and -2). that include:. prostaglandins, thromboxanes, . leukotrienes. , & related compounds. . . They are generated from . phospholipid. precursors. . They function primarily as hormone-like chemical signals between cells.. is a Generic term for the 20 Carbon related compounds like:. Prostaglandins (PGs). Prostacyclins (PGI2). Thromboxanes (TX). Leukotrienes (LT). Lipoxins (LX). Resolvins. Eoxins. Biosynthesis Of Eicosanoids. Eicosanoids. Several Classes of Signal Molecules:. . P. rosta. g. landins, Thromboxanes, Leukotrienes. Produced In Almost all Tissues. Wide Range of Responses. Local Hormones. Very Potent. Short Half Life . Acids & . Eicosanoids. BIOMEDICAL IMPORTANCE. Unsaturated fatty acids in phospholipids of the cell. membrane are important in maintaining membrane. fluidity. A high ratio of polyunsaturated fatty acids to. In 1935, this term was introduced by Von Euler for the bioactive substance produced by prostate . glands.. Now these substances have been detected in almost all animal tissue cells.. They play an vital role in cell function and cellular metabolism.. Eicosanoids. Prof. Mamoun Ahram. Resources. This lecture. Lippincott’s Biochemistry, Ch. 17. Eicosanoid Metabolism: Prostaglandins, Thromboxanes, Leukotrienes, and Lipoxins (. https://themedicalbiochemistrypage.org/eicosanoid-metabolism-prostaglandins-thromboxanes-leukotrienes-and-lipoxins/. Autacoids are . are. biological factors which act like local hormones, have a brief duration, and act near the site of synthesis. The word autacoids comes from the Greek "Autos" (self) and ". Acos. SUHAS AGEY. Asst professor, . Dept of Pharmacology. Hrpiper, Shirpur. Contents . Introduction. Chemistry, biosynthesis . COX pathways . Prostaglandins . Classification . P’cological and patho. role.