PPT-Prostaglandins (PGs) and Thromboxanes (TXs)-Synthesis and Degradation

Dr Arthur Roberts Modified from course of Dr Warren Beach Materials ELCnew pharmwikiorg updated lectures Notes on the updates class notes from the current lectures lectures and notes from previous years. 1. Dr. Nikhat Siddiqi. Prostaglandins, and the related compounds . thromboxanes. and . leukotrienes. , are collectively known as . eicosanoids. to reflect their origin from polyunsaturated fatty acids with 20 carbons. . UNIT III:. Lipid Metabolism. Part 3. Prostaglandins. , and the related compounds . thromboxanes. and leukotrienes, are collectively known as eicosanoids to reflect their origin from polyunsaturated fatty acids with 20 . catalytics. :. https://. learningcatalytics.com. /. If you haven’t created an account do so now!. Use LRFM4V7 as the code when you sign up. Our session number for today is. : . 538246. What is the point of a signal transduction pathway. Prof. S. . Kajuna.  . The . prostaglandins. are a group of . lipid. compounds that are derived . enzymatically. from . fatty acids. and have important functions in the . animal. body. Every prostaglandin contains 20 . 1. . Overview. The catabolism of the amino acids involves:. Removal of α-amino groups. . Breakdown of the resulting carbon skeletons.. The resulting compounds will be used to form seven intermediate products: . Dr. . Haitham. M. Al-. Wali. P. h. .D. Pharmacology. 22 February 2018. 1. PROSTAGLANDINS. The NSAIDs act by inhibiting the synthesis of prostaglandins. Thus, an . understanding of . NSAIDs requires comprehension of the actions and . PGs, TXs, LTs). Objectives:. . Discover and distinguish relationships between . different types of eicosanoid molecules . (PGs, TXs, LTs). Gain knowledge of enzymes that create PGs . and TXs (COX-1 and -2). is a Generic term for the 20 Carbon related compounds like:. Prostaglandins (PGs). Prostacyclins (PGI2). Thromboxanes (TX). Leukotrienes (LT). Lipoxins (LX). Resolvins. Eoxins. Biosynthesis Of Eicosanoids. Conversion of Amino Acids to Specialized Products . 1. . Overview . In addition to serving as building blocks for proteins, amino acids are precursors of many nitrogen-containing compounds that have important physiologic functions (Figure 21.1). . Eicosanoids. Several Classes of Signal Molecules:. . P. rosta. g. landins, Thromboxanes, Leukotrienes. Produced In Almost all Tissues. Wide Range of Responses. Local Hormones. Very Potent. Short Half Life . Acids & . Eicosanoids. BIOMEDICAL IMPORTANCE. Unsaturated fatty acids in phospholipids of the cell. membrane are important in maintaining membrane. fluidity. A high ratio of polyunsaturated fatty acids to. 2. Aged proteins, damaged or modified proteins and non-functional proteins of the body undergo degradation. . 3. Protein degradation may play important role in shaping tissues and organs during pregnancy and development.. In 1935, this term was introduced by Von Euler for the bioactive substance produced by prostate . glands.. Now these substances have been detected in almost all animal tissue cells.. They play an vital role in cell function and cellular metabolism.. Eicosanoids. Prof. Mamoun Ahram. Resources. This lecture. Lippincott’s Biochemistry, Ch. 17. Eicosanoid Metabolism: Prostaglandins, Thromboxanes, Leukotrienes, and Lipoxins (. https://themedicalbiochemistrypage.org/eicosanoid-metabolism-prostaglandins-thromboxanes-leukotrienes-and-lipoxins/.