PPT-1 B Cells and Antibodies

Abul K Abbas UCSF FOCiS 2 Lecture outline Functions of antibodies B cell activation the role of helper T cells in antibody production Therapeutic targeting of B cells 3 Humoral immunity is the defense mechanism against extracellular microbes . 6.5 Antibodies . Learning outcomes. Student should be able to understand the following:. Antibody structure and the formation of an antigen-antibody complex. The use of monoclonal antibodies in enabling the targeting of specific substances and cells.. and allograft injury: more than you think. Geetha Chalasani, MD. Departments of Medicine (Renal-Electrolyte) and Immunology. Thomas E. . Starzl. Transplantation Institute. University of Pittsburgh School of . Human Health and Physiology. 11.1 Defense Against Infectious Diseases . 11.1.1 Describe the process of blood clotting . 11.1.2 Outline the principle of challenge and response, clonal selection and memory cells as the basis of immunity . Blood. What Exactly is BLOOD??. Fluid portion of blood= PLASMA. Primarily water and is 55% of the blood. Suspended in the plasma are solid materials, mostly types of cells: red blood cells, white blood cells, and platelets. mAbs. ): . Three Decades Of Innovation And Progress. History Of Discovery. . Discovery . of tetanus and diphtheria . antitoxins. 2. Paul Ehrlich proposes “Side-Chain Theory” for antibody & antigen (lock & key) interaction. Reported by . Ganesh . M.Sc.D. . endo. student. What is immunoglobulin ?. Immunoglobulin's . are glycoprotein molecules that are produced by plasma cells in response to an immunogen and which function as antibodies. The . What are lymphocytes?. Lymphocytes. are a type of white blood cell (. leukocyte. ) found in the blood and lymph nodes. . Collectively, lymphocytes can recognize millions of different antigens, due to the large variation of lymphocytes produced. . In the 1880s German doctor, Robert Koch, developed a series of methods for identifying which organism was the cause of a particular disease. These postulates are still in use today.. This led the way for specific treatment for many disease- causing pathogens.. Enas. . Razzoqi. . B.D.S., M.Sc., . Ph.D. in . Periodontics. . Most important cytokines are. Cytokines are group of small soluble proteins or . glycoproteins. secreted by different cells in the body, usually in response to stimulation which act as messenger molecules transmitting signals to other cells and induced responses through binding to specific receptors to control and coordinate cellular behavior and function . Lec.4. . Dr. Mustafa Jawad. Definition of Immunoglobulins (Igs). Immunoglobulins, also known as . antibodies. , are glycoprotein molecules produced by . plasma cells . (B-cell). . They . act as a critical part of the immune response by specifically . .. . Paul Ehrlich had first introduced the concept of autoimmunity; he termed this condition as “horror . autotoxicus. ”.. AUTOIMMUNITY. Normally immune system does not react to its own antigens due to a protective mechanism called tolerance. . Learning outcomes. Student should be able to understand the following:. Antibody structure and the formation of an antigen-antibody complex. The use of monoclonal antibodies in enabling the targeting of specific substances and cells.. antiphospholipid. syndrome. A short . tributededicated. to the memory of Dr. Virgil Woods Jr.: brilliant and generous scientist, dedicated mentor, and truly compassionate physician. by. Nunzio. Bottini, MD, PhD. A case study approach to the use of the labs:. chemical pathology, virology, bacteriology, cellular pathology and antibody detection. Professor Karim Meeran, . Dr Mark Atkins, Dr Hugo Donaldson, . Dr Keith Gould and Professor Robert .