parasympathetic ch olinergi c fibers acetylcholine sympathetic AM adrenergic fibers norepinephrine epinephrine αreceptor s metabotrop ic βreceptor s metabotrop ID: 277446
Download Presentation The PPT/PDF document "AUTONOMIC NERVOUS SYSTEM" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
AUTONOMIC NERVOUS SYSTEM
parasympathetic(cholinergic fibers)acetylcholine
sympathetic + AM(adrenergic fibers)norepinephrine + epinephrine
α-receptors(metabotropic)
β-receptors(metabotropic)
nicotinic r.(ionotropic)
muscarinic r.(metabotropic)
α1
α2
β1
β2
β3
muscle type
neuronal type
M1 – M5
NE – excites mostly α, less β
epinephrine – excites both subtypes
ACh – excites both subtypes
nicotine – nicotinic r.; muscarine – muscarinic r.Slide2
α1
α2β1
β2
β3muscle typeneuronal
typeM1 – M5
NE – excites mostly α, less βepinephrine – excites both subtypesACh – excites both subtypes
nicotine – nicotinic
r; muscarine
– muscarin
ic r.
AGONISTS:phenylephrine –
α1clonidine
– α2
AGONISTS:isoproterenol
– β1 + β2
dobutamine – β
1albuterol (
salbutamol) – β2
RELEASE FROM NERVE ENDINGS:ephedrine, tyramine, amphetamineANTAGONISTS:phentolamine, phenoxybenzamine – α1 + α
2prazosin
– α1
yohimbine, rauwolscine
– α2
ANTAGONIST
S:propranolol
– β
1 + β
2 metoprolol
, atenolol –
β1
BLOCKING SYNTHESIS AND STORAGE OF N
E: res
erpin
e
BLOCKING RELEASE OF
N
E
: g
u
anet
h
idin
e
BLOCKING
TRANSMISSION THROUGH
GANGLI
A
:
hexamethonium
,
tetraet
hylammonium, pentolinium
AGONISTS:methacholine, carbachol, nicotine
AGONISTS:pilocarpine, methacholine
ANTICHOLINESTERASE DRUGS:neostigmine, physostigmine, ambenoniumdiisopropyl fluorophosphate – ireversibile
ANTAGONISTS(ANTIMUSCARINIC D.):atropine, homatropine, scopolamine
ANTAGONIST
S
:
c
urariform
drugs