AssistLecturer Aseel Ghassan Daoud MSc In pharmacy Clinical laboratory sciences What is urea Urea is the main end product of protein metabolism It is formed by removal of amino group from amino acids in liver and excreted in urine ID: 638064
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Slide1
Blood Urea
Presented By
Assist.Lecturer
Aseel
Ghassan
Daoud
M.Sc. In pharmacy/ Clinical laboratory sciencesSlide2
What is urea?Urea is the main end product of protein metabolism.
It is formed by removal of amino group from amino acids in liver and excreted in urine.
Urea represents 50% of non protein nitrogen of normal blood.Slide3
Normal blood contains 15-40 mg/dl
of urea
In adults over 60 years it rises to
50 mg/dl
During pregnancy it is
15-20 mg/dl
Raised values are seen in dehydration
In renal failure it rises up to
500 mg/dl
In sever liver disease blood urea is decreasedSlide4
Reference values:
Newborns (< 10 days) : 6.4-53.5 mg/dl
Adults (12-60 years) : 15-40 mg/dl
Physiological:
Increase:
It occurs in normal people on high protein diet.Slide5
Decrease:
I
n
infants
Pregnancy
Low protein and high carbohydrates dietSlide6
Pathological:Increase:
Excessive formation:
increased protein catabolism in fever and sepsis. Slide7
Faulty excretion:Pre-renal failure: a low renal blood supply leads to reduced GFR ex:
CHF
Renal failure: damage to nephrons leads to decreased urine formation and excretion ex:
nephritis
Post-renal failure:
urinary tract obstructions
Slide8
Decrease:In transfusion of glucose solution due to dilution of body fluids and reduced protein catabolism
What are medicines that increase blood urea?
A
mphotericin B
Nafcilline
Gentamicin
Diuretics
Corticosteroids