PPT-Neuropathology of Cytochrome b Deficiency

Boleslaw Lach Mark Tarnopolsky Janet Simons Samantha Marin Lauren MacNeil and Steve Sommer McMaster University CYTOCHROME B DEFICIENCY Encoded by mDNA One out of 11 polypeptides of complex III. . Cytochrome C in Humans Compared to Other Species Using Bioinformatics. We live in a human-centric world.. Human Metabolism. Sugar +. O. xygen. Energy!. Aerobic respiration. 1. Glycolysis. 2. Citric acid cycle. Part I. Give a description of your organism.. H. omo . s. apiens. is the primate species to which all modern humans belong. . . The . closest relatives are chimpanzees from which they are distinguished by greater size, a peculiar distribution of hair, and a larger carbon footprint. . Julia . Kofler. and Kate McFadden. Outline. The CNS Autopsy. Dura removal. Spinal cord squeeze. Basic . Neuroanatomy. Gross Neuropathology. Bloody brain. The CNS Autopsy. Examination of the brain and spinal cord at autopsy is performed to diagnose diseases affecting the CNS and to correlate lesion type/ patterning with . We live in a human-centric world.. Life exists outside our box.. Subtitle. Text. Shock & Holland (2007). For example, there is life deep down on the ocean floor.. C-DEBI . (Center for Deep Energy Biosphere Investigations). The flow of electrons from NADH and FADH. 2. to O. 2. occurs in the electron-transport chain or respiratory chain.. This exergonic set of oxidation–reduction reactions generates a proton gradient.. Introduction. ETC is a process in which NADH and FADH. 2 . . which are the byproducts of catabolic processes (such as . glycolysis. , . b. -oxidation, etc) and are present in their reduced form are oxidized and release energy in the form of ATP (. RBC enzymopathies. Abnormalities of RBC enzymes cause Hereditary . N. onspherocytic. Hemolytic . A. nemia(HNSHA). As RBCs mature they lose their nucleus, mitochondria and other organelles which causes them to not be able to carry out oxidative phosphorylation and protein synthesis. . CPP32 can cleave PARP. DNA fragmentation experiment. Addition of . dATP. can activate CPP32 in . Hela. cell S-100. Cleavage of SREBP by CPP32. All equally important. What can you conclude from Figure 3?. Julia . Kofler. and Kate McFadden. Outline. The CNS Autopsy. Dura removal. Spinal cord squeeze. Basic . Neuroanatomy. Gross Neuropathology. Bloody brain. The CNS Autopsy. Examination of the brain and spinal cord at autopsy is performed to diagnose diseases affecting the CNS and to correlate lesion type/ patterning with . Xiaowei Su, PGY-3 & Dr. Geoffrey Murdoch. Adapted from slides by . jen. . nichols. and . robyn. massa. Bacterial Meningitis. Meningitis is an inflammatory disease of the leptomeninges. Abnormal number of white blood cells in the CSF. Hom. ); . M.Sc. . (Counselling and Psychotherapy). Associate Professor; Forensic Medicine and Toxicology; . Sarada. Krishna Homoeopathic Medical College . Kulasekharam. Irritants : gases injure the air passages or lungs or both and produce inflammatory changes. Smoke, tear gases, ammonia, phosgene etc.. 3rd Stage . College of Pharmacy . Al-. Mustansiriyah. University. Dr. . Basma. Al- . Sudani. Lecture . 5. 27-6-2021. BIOMEDICAL IMPORTANC. Xenobiotics. are a wide variety of foreign chemicals , both naturally occurring compounds in plant foods, and synthetic compounds in medicines, food additives, and environmental pollutants.. Aman. Edited by Margaret Hilton. Honors Organic Chemistry. Chem. 2321 (. Sigman. ), 2013. Cytochrome P450 Oxidase. Overview. : . Cytochrome P450 Oxidases (CYPs) are the principal enzymes implicated in drug metabolism, catalyzing approximately 75% of reactions (1). The . west. Prepared By:. Rakiaa. Michael Saeed. Supervised by:. Asst. Prof. Dr. . Gulzar. I. Ibrahim. . Introduction . However, the term . xenobiotics. is very often used in the context of pollutants such as dioxins and polychlorinated biphenyls and their effect on the biota, because .