PPT-Hemoglobin Synthesis

b d g a a Chromosome 16 Chromosome 11 25 25 a a b d g 25 25 48 48 15 05 15 05 Hemoglobin synthesis a a a a a a b g d b d g HbA HbF HbA 2 98 1. . Electrophoresis. Electrophoresis. Electrophoresis is a means of separating hemoglobin's. . . It depends on the migration of the hemoglobin molecules dissolved in a buffer on, or in, a supporting medium when an electric current is passed through them. . Parts 1-4 – Data Extraction, Quality Assessment, Synthesising Across Studies, . Completing the Analysis. Workshop: . Framework Synthesis, Meta-Ethnography and Realist Synthesis . Shared Topic: . and Function. Chapter 3: . Globular . Proteins. Part . 2. II. GLOBULAR HEMEPROTEINS. E. Allosteric effects. Binding . of . CO. 2. : . Most . of the . CO. 2. produced . in . metabolism is hydrated . and transported as bicarbonate . Discuss with your group.. Be prepared to share your answers. . The Hardest Part. The synthesis section is the hardest part of the exam. It is worth . 47. % . of the entire exam!. 17 % -- multiple choice. Hemoglobin variant trait is common and can occur in any race or ethnicity You may have heard of sickle cell trait before while not exactly the same sickle cell trait and hemoglobin variant trait are s Adult male: 4.6 – 6 million. Adult female: 4.2 – 5 million. Red blood cells are: . Tiny, flexible biconcave discs. Lacks a nucleus. Can bend when going through tiny capillaries. RBC’s are constantly manufactured. Learning Objectives. ▪ . Hemoglobinopathies. (Abnormal . Hb. . variants). ▪. Different . Hemoglobin . combinations-. Nr. and . Abn. •. Sickle . cell trait is the . heterozygous form . of the . April 12, 2014. Virginia Harrod, MD, PhD. Pediatric Hematology Oncology. Overview . Definition of anemia. Review of CBC values. Review of Hemoglobin. Types of Anemia. Microcytic, macrocytic, normocytic. and . Hb. synthesis. Dr. Sunita Mittal. Learning Objectives. ▪. Factors affecting erythropoiesis. ▪. Hemoglobin synthesis. Factors regulating Erythropoiesis. Φ. . Growth or Developmental Factors. . By – . Dr. Sunita Mittal. Learning Objectives. ▪. Iron metabolism . ▪. Hemoglobin catabolism (Fate of old RBCs) . ▪. Prehepatic. Jaundice. Iron . (Fe. +2. ) Metabolism. Iron is essential for . Svjetlana Kalanj Bognar (. svjetla. na.kalanj.bognar. @mef.hr. ). Myoglobin. . and. hemoglobin, . oxygen-binding. . proteins. evolutionary. . demands. . of. . multicellular. . organisms. . and. Hemoglobin. . Found in the RBC.. Responsible for carrying oxygen to all cells in the body.. Also binds to carbon dioxide and carries it to the lungs from the cells to be released.. Buffer against change in [H. Hb. ) have related, but different, roles in the body. Hemoglobin:. Found in red blood cells. Promotes diffusion of O. 2 . throughout the body (binds O. 2 . at lungs,. . releases at tissues). Myoglobin:. Prof. Mamoun Ahram. Blood module. 2019. Heme structure. It is a complex of . protoporphyrin. IX + Iron (Fe. 2+. ).. The porphyrin is planar and consists of four rings (designated A-D) called pyrrole rings..