PPT-Iron metabolism & Hemoglobin catabolism

By Dr Sunita Mittal Learning Objectives Iron metabolism Hemoglobin catabolism Fate of old RBCs Prehepatic Jaundice Iron Fe 2 Metabolism Iron is essential for . . Electrophoresis. Electrophoresis. Electrophoresis is a means of separating hemoglobin's. . . It depends on the migration of the hemoglobin molecules dissolved in a buffer on, or in, a supporting medium when an electric current is passed through them. Lecture . 7 . 1. White blood cells. Platelets. Red blood cells. Artery. Introduction . . 2. Physical Characteristics of . Blood. Heavier, thicker, and 3-4 . more . viscous than water. 38. o. C (100.4. IRON OVERLOAD. IRON. 10-15 mg/day in diet; 5-10% absorbed. Absorption increased in iron deficiency, pregnancy, erythroid hyperplasia, hypoxia. Heme iron absorbed best. Fe. 2 . much better than Fe. 3 . H2500 Hemoglobin Bovine Lyophilized powder H3760 Hemoglobin Bovine Dried erythrocytes Methemoglobin and oxyhemoglobin content is not determined H2625 Hemoglobin Bovine Substrate powder Prepar Definition of Anemia. Who here is anemic?. Newborn baby boy with hemoglobin 12.8 g/. dL. 2 month-old baby girl with . hgb. 9.5 g/. dL. 4 year-old girl with . hgb. 10.6 g/. dL. 16 . y.o. . boy with . April 12, 2014. Virginia Harrod, MD, PhD. Pediatric Hematology Oncology. Overview . Definition of anemia. Review of CBC values. Review of Hemoglobin. Types of Anemia. Microcytic, macrocytic, normocytic. By Louann W. Lawrence, Larry A. Broussard . Introduction. Porphyrins, hemoglobin, & myoglobin all contain porphyrin ring: 4 pyrrole groups bonded by methene bridges.. Porphyrins can chelate metals . globin. chains. Abnormalities in these proteins are referred to as . hemoglobinopathies. Two hemoglobin gene clusters are involved in the production of hemoglobin and are located at the end of the short arm of chromosomes 16 and 11, respectively. . Svjetlana Kalanj Bognar (. svjetla. na.kalanj.bognar. @mef.hr. ). Myoglobin. . and. hemoglobin, . oxygen-binding. . proteins. evolutionary. . demands. . of. . multicellular. . organisms. . and. Metabolism . https. ://. www.youtube.com/watch?v=5qjgEKqVkSo . Do all organisms have the same energy needs?. Chemical reactions are divided into what two . categories? . What are two ways organisms can obtain their energy?. THALASSEMIA. It result from reduced or absent production of beta chain in globin.. Common Hereditary Hemoglobin disorder(HHD). A. ) . Beta- . Thalassemia:Major,Intermedia,Minor. (trait . or carrier). ESSAM . AHMED. M.B.Ch.B. , F.I.B.M.S. Peadiatric. . Hemato. -Oncologist. Objectives. 1- to understand the definition of anemia and recognize its different types according to . their etiology. 2- to be able to approaches to patient with anemia (investigations and treatment. Hemoglobin. . Found in the RBC.. Responsible for carrying oxygen to all cells in the body.. Also binds to carbon dioxide and carries it to the lungs from the cells to be released.. Buffer against change in [H. 471. Objectives. Quantitative determination of hemoglobin in a blood sample.. . Hemoglobin structure. Hemoglobin (. Hb. ) is a . porphyrin. –iron (II) . protien. in RBCs that transport oxygen from the lungs to the rest of the body and carbon dioxide back to the lungs..