and Hb synthesis Dr Sunita Mittal Learning Objectives Factors affecting erythropoiesis Hemoglobin synthesis Factors regulating Erythropoiesis Φ Growth or Developmental Factors ID: 917359
Download Presentation The PPT/PDF document "Factors affecting Erythropoiesis" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
Factors affecting Erythropoiesis and Hb synthesis
Dr
Sunita Mittal
Slide2Learning Objectives▪Factors affecting erythropoiesis
▪
Hemoglobin synthesis
Slide3Factors regulating ErythropoiesisΦ Growth or Developmental Factors
Φ
Nutritional Factors
Φ
Hormonal Factors
Φ
Healthy Liver and Bone
marrow
Slide4Hemopoietic Growth Factors - cytokines
Slide5Hemopoietic Growth Factors-EPO (Erythropoietin)
A glycoprotein hormone (mw 34000 d) and a cytokine
(
protein
signaling
molecule
)
for
erythrocyte precursors
in the bone
marrow.
90
% from the kidney
10
% form the
liver
Slide6Nutritional Factors regulating Erythropoiesis
A) Proteins:
B
) Minerals:
Iron
(Fe
++
)
2
. Copper (Cu
++
)
3
. Cobalt (Co
)
Slide7Nutritional Factors regulating Erythropoiesis
C) Vitamins:
Slide8▫Thyroid ▫ Cortisol▫ Androgens
Hormonal Factors regulating Erythropoiesis
Slide9●
Liver
●
Bone
marrow
Regulation of Erythropoiesis - Liver and Bone marrow
Slide10The hemoglobin is pigmented globular protein structure Hemoglobin
Slide11HemoglobinFunctionStructureConsists of 4 Subunits-
▪
Heme
group
▪
Globin
chain
Slide12Hemoglobin SynthesisHeme synthesis starts in Mitochondria of
normoblast
with the
condensation of
G
lycine
and
S
uccinyl
C
oenzyme
A
Slide13Hemoglobin Synthesis
Slide14Which is not true for free Hb in blood-a) it increase the blood viscosityb) increase the osmotic/oncotic pressurec) it can be lost by kidneys in urine
d) it damages the
liver
Normal reticulocyte count at birth
is-
a)1-2%
b)<1%
c)5-10%
d)2-6
%
Erythropoietin is secreted
from-
a)Kidney
b)Liver
c)tissue macrophage
d)spleen
life span of foetal RBC - a)120 days b)120 weeks c) 80 days d) 80 weeks Self Assessment
Slide15Thank you